CAS 19388-87-5|Taurolidine
| Common Name | Taurolidine | ||
|---|---|---|---|
| CAS Number | 19388-87-5 | Molecular Weight | 284.356 |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 471.2±55.0 °C at 760 mmHg |
| Molecular Formula | C7H16N4O4S2 | Melting Point | 156ºC |
| MSDS | USA | Flash Point | 238.8±31.5 °C |
Names
| Name | Taurolidine |
|---|---|
| Synonym | More Synonyms |
Taurolidine BiologicalActivity
| Description | Taurolidine is a broad-spectrum antimicrobial for the prevention of central venous catheter-related infections. Taurolidine has a direct and selective antineoplastic effect on brain tumor cells by the induction of apoptosis[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerResearch Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
| References | [1]. Haro C, et al. Taurolidine, an antiseptic for the prevention of central venous catheter-related infections. Rev Chilena Infectol. 2019 Aug;36(4):414-420. [2]. Stendel R, et al. Treatment of glioblastoma with intravenous taurolidine. First clinical experience. Anticancer Res. 2004 Mar-Apr;24(2C):1143-7. |
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 471.2±55.0 °C at 760 mmHg |
| Melting Point | 156ºC |
| Molecular Formula | C7H16N4O4S2 |
| Molecular Weight | 284.356 |
| Flash Point | 238.8±31.5 °C |
| Exact Mass | 284.061310 |
| PSA | 115.58000 |
| LogP | -2.55 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.564 |
| InChIKey | AJKIRUJIDFJUKJ-UHFFFAOYSA-N |
| SMILES | O=S1(=O)CCN(CN2CCS(=O)(=O)NC2)CN1 |
Safety Information
| RIDADR | NONH for all modes of transport |
|---|---|
| HS Code | 2933990090 |
Customs
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles34
More Articles| Taurolidine induces epithelial-mesenchymal transition via up-regulation of the transcription factor Snail in human pancreatic cancer cell lines. Int. J. Colorectal Dis. 29(11) , 1339-48, (2014) The taurine derivative taurolidine (TRD) exerts anti-neoplastic effects in a variety of tumor models. On the other hand, TRD at low doses was shown to reduce cell-cell adhesion, a prerequisite for met... | |
| Central venous catheters and catheter locks in children with cancer: a prospective randomized trial of taurolidine versus heparin. Pediatr. Blood Cancer 60(8) , 1292-8, (2013) To determine if the catheter lock taurolidine can reduce the number of catheter-related bloodstream infections (CRBSI) in pediatric cancer patients with tunneled central venous catheters (CVC).During ... | |
| Taurolidine specifically inhibits growth of neuroblastoma cell lines in vitro. J. Pediatr. Hematol. Oncol. 36(4) , e219-23, (2014) Neuroblastoma is a common pediatric solid tumor with poor outcome for metastatic disease. Thus, novel therapeutic options are of main interest. The anti-neoplastic properties of taurolidine have been ... |
Synonyms
| 4,4'-Methylenebis(tetrahydro-1,2,4-thiadiazine) 1,1,1',1'-tetraoxide |
| 4,4'-methanediylbis(1,2,4-thiadiazinane) 1,1,1',1'-tetraoxide |
| 2H-1,2,4-Thiadiazine, 4,4'-methylenebis[tetrahydro-, 1,1,1',1'-tetraoxide |
| 4,4'-Methylenebis(tetrahydro-1,2,4-sulfadiazine 1,1-dioxide) |
| 4,4'-Methylenebis(perhydro-1,2,4-thiadiazine 1,1-dioxide) |
| Bis(1,1-dioxoperhydro-1,2,4-thiadiazin-4-yl)methane |
| 4,4'-Methylenebis(1,2,4-thiadiazinane) 1,1,1',1'-tetraoxide |
| Taurolin |
| Taurolidine |
| Tauroline |
