CAS 67-16-3|Thiamine Disulfide Hydrate

Introduction：Basic information about CAS 67-16-3|Thiamine Disulfide Hydrate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Thiamine Disulfide Hydrate BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Thiamine Disulfide Hydrate
CAS Number	67-16-3	Molecular Weight	562.708
Density	1.4±0.1 g/cm3	Boiling Point	886.1±65.0 °C at 760 mmHg
Molecular Formula	C₂₄H₃₄N₈O₄S₂	Melting Point	177ºC
MSDS	/	Flash Point	489.7±34.3 °C

Names

Name	Thiamine Disulfide Hydrate
Synonym	More Synonyms

Thiamine Disulfide Hydrate BiologicalActivity

Description	Thiamine disulfide, a vitamin B1 derivative, is an oxidized dimer of Thiamine. Thiamine disulfide is a potent HIV-1 inhibitor. Thiamine disulfide significantly depresses HIV-1 transactivator (Tat) activity[1][2].
Related Catalog	Signaling Pathways >>Anti-infection >>HIVResearch Areas >>InfectionResearch Areas >>Metabolic Disease
In Vitro	Thiamine disulfide markedly inhibits production of progeny HIV-1 in acute and chronic HIV-1-infected CEM at nontoxic concentrations of 500-1000 μM. Thiamine disulfide (500 μM) blocks 99.7% of HIV-1 production after 96 hours culture in acute HIV-1 (LAV-1) infection, whereas it inhibits 90-98% of HIV-1 production in chronic-infected cells (CEM/LAV-1, H9/MN, and Molt-4/IIIB)[1].
References	[1]. S Shoji, et al. Thiamine disulfide as a potent inhibitor of human immunodeficiency virus (type-1) production. Biochem Biophys Res Commun. 1994 Nov 30;205(1):967-75. [2]. Y Komata, et al. In vitro percutaneous absorption of thiamine disulfide from a mixture of propylene glycol and fatty acid. J Pharm Sci. 1992 Aug;81(8):744-6.

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Boiling Point	886.1±65.0 °C at 760 mmHg
Melting Point	177ºC
Molecular Formula	C₂₄H₃₄N₈O₄S₂
Molecular Weight	562.708
Flash Point	489.7±34.3 °C
Exact Mass	562.214417
PSA	235.28000
LogP	2.79
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.669
InChIKey	GFEGEDUIIYDMOX-YHARCJFQSA-N
SMILES	CC(=C(CCO)SSC(CCO)=C(C)N(C=O)Cc1cnc(C)nc1N)N(C=O)Cc1cnc(C)nc1N

Safety Information

RTECS	LQ2715000

Synonyms

Formamide, N,N'-[dithiobis[(Z)-2-(2-hydroxyethyl)-1-methyl-2,1-ethenediyl]]bis[N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-

MFCD00010427

Thiamine Disulfide

Vitamin B1 Disulfide

EINECS 200-644-4

Aneurine Disulfide

AKTIVIN

N,N'-{Disulfanediylbis[(2Z)-5-hydroxypent-2-ene-3,2-diyl]}bis{N-[(4-amino-2-methylpyrimidin-5-yl)methyl]formamide}

N,N'-{Disulfanediylbis[(2Z)-5-hydroxy-2-pentene-3,2-diyl]}bis{N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]formamide}

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