CAS 83-72-7|2-Hydroxy-1,4-naphoquinone
Introduction：Basic information about CAS 83-72-7|2-Hydroxy-1,4-naphoquinone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 2-Hydroxy-1,4-naphoquinone | ||
|---|---|---|---|
| CAS Number | 83-72-7 | Molecular Weight | 174.153 |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 339.9±42.0 °C at 760 mmHg |
| Molecular Formula | C10H6O3 | Melting Point | 192-195 °C (dec.)(lit.) |
| MSDS | ChineseUSA | Flash Point | 173.6±24.4 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | lawsone |
|---|---|
| Synonym | More Synonyms |
2-Hydroxy-1,4-naphoquinone BiologicalActivity
| Description | Lawsone is a naphthoquinone dye isolated from leaves of Lawsonia inermis that shows antimicrobial and antioxidant activity[1]. |
|---|---|
| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Fungal |
| References | [1]. Tripathi RD, et al. A fungitoxic principle from the leaves of lawsonia inermis lam. Experientia. 1978 Jan 15;34(1):51-2. |
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 339.9±42.0 °C at 760 mmHg |
| Melting Point | 192-195 °C (dec.)(lit.) |
| Molecular Formula | C10H6O3 |
| Molecular Weight | 174.153 |
| Flash Point | 173.6±24.4 °C |
| Exact Mass | 174.031693 |
| PSA | 54.37000 |
| LogP | 1.55 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.681 |
| InChIKey | WVCHIGAIXREVNS-UHFFFAOYSA-N |
| SMILES | O=C1C=C(O)c2ccccc2C1=O |
| Water Solubility | 2 g/L (20 ºC) |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 522 mg/kg/6D-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in spleen Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases
MUTATION DATA - TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 50 mg/kg
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 343,61,1995 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9568 No. of Facilities: 227 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 2271 (estimated) No. of Female Employees: 1817 (estimated)
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 50 mg/kg
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 343,61,1995 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9568 No. of Facilities: 227 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 2271 (estimated) No. of Female Employees: 1817 (estimated)
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn:Harmful; |
| Risk Phrases | R22;R36;R68 |
| Safety Phrases | S26-S37/39-S36/37/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | QL8200000 |
| Packaging Group | II |
| HS Code | 2914690090 |
Customs
| HS Code | 2914690090 |
|---|---|
| Summary | 2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |
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Synonyms
| C.I. Natural Orange 6 |
| MFCD00001678 |
| 2-Hydroxy-1,4-naphthochinone |
| 2-Hydroxy-1,4-naphoquinone |
| EINECS 201-496-3 |
| 2-Hydroxy-1,4-naphthoquinone |
| hydroxynaphthoquinone |
| Natural Orange 6 |
| 1,4-Naphthalenedione, 2-hydroxy- |
| 2-Hydroxy-p-naphthoquinone |
| 2-hydroxynaphthalene-1,4-dione |
| hennotannic acid |
| lawsone |
| 2-Hydroxy-1,4-napthoquinone |
