CAS 30636-90-9|(20S)-Protopanaxdiol

Introduction：Basic information about CAS 30636-90-9|(20S)-Protopanaxdiol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. (20S)-Protopanaxdiol BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	(20S)-Protopanaxdiol
CAS Number	30636-90-9	Molecular Weight	460.732
Density	1.0±0.1 g/cm3	Boiling Point	559.5±40.0 °C at 760 mmHg
Molecular Formula	C₃₀H₅₂O₃	Melting Point	211 °C
MSDS	/	Flash Point	226.1±21.9 °C

Names

Name	(20S)-protopanaxadiol
Synonym	More Synonyms

(20S)-Protopanaxdiol BiologicalActivity

Description	(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin; apoptosis inducer.IC50 value:Target: apoptosis inducer(20S)-Protopanaxadiol was used to induce cytotoxicity for two human glioma cell lines, SF188 and U87MG. For the SF188 cells, (20S)-Protopanaxadiol activated caspases-3, -8, -7, and -9 within 3 h and induced rapid apoptosis, which could be partially inhibited by a general caspase blocker and completely abolished when the caspase blocker was used in combination with an antioxidant. (20S)-Protopanaxadiol also induced cell death in U87MG cells but did not activate any caspases in these cells [1]. aPPD was able to inhibit P-gp activity as potently as verapamil on MDR cells. The blockage of P-gp activity was highly reversible as wash-out of aPPD resulted in an immediate recovery of P-gp activity. Unlike verapamil, aPPD did not affect ATPase activity of P-gp suggesting a different mechanism of action [2].
Related Catalog	Signaling Pathways >>Membrane Transporter/Ion Channel >>P-glycoproteinNatural Products >>SteroidsResearch Areas >>Cancer
References	[1]. Liu GY, et al. 20S-protopanaxadiol-induced programmed cell death in glioma cells through caspase-dependent and -independent pathways. J Nat Prod. 2007 Feb;70(2):259-64. [2]. Zhao Y, et al. 20S-protopanaxadiol inhibits P-glycoprotein in multidrug resistant cancer cells. Planta Med. 2009 Aug;75(10):1124-8.

Description

(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin; apoptosis inducer.IC50 value:Target: apoptosis inducer(20S)-Protopanaxadiol was used to induce cytotoxicity for two human glioma cell lines, SF188 and U87MG. For the SF188 cells, (20S)-Protopanaxadiol activated caspases-3, -8, -7, and -9 within 3 h and induced rapid apoptosis, which could be partially inhibited by a general caspase blocker and completely abolished when the caspase blocker was used in combination with an antioxidant. (20S)-Protopanaxadiol also induced cell death in U87MG cells but did not activate any caspases in these cells [1]. aPPD was able to inhibit P-gp activity as potently as verapamil on MDR cells. The blockage of P-gp activity was highly reversible as wash-out of aPPD resulted in an immediate recovery of P-gp activity. Unlike verapamil, aPPD did not affect ATPase activity of P-gp suggesting a different mechanism of action [2].

Related Catalog

Signaling Pathways >>Membrane Transporter/Ion Channel >>P-glycoproteinNatural Products >>SteroidsResearch Areas >>Cancer

References

[1]. Liu GY, et al. 20S-protopanaxadiol-induced programmed cell death in glioma cells through caspase-dependent and -independent pathways. J Nat Prod. 2007 Feb;70(2):259-64.

[2]. Zhao Y, et al. 20S-protopanaxadiol inhibits P-glycoprotein in multidrug resistant cancer cells. Planta Med. 2009 Aug;75(10):1124-8.

Chemical & Physical Properties

Density	1.0±0.1 g/cm3
Boiling Point	559.5±40.0 °C at 760 mmHg
Melting Point	211 °C
Molecular Formula	C₃₀H₅₂O₃
Molecular Weight	460.732
Flash Point	226.1±21.9 °C
Exact Mass	460.391632
PSA	60.69000
LogP	7.59
Vapour Pressure	0.0±3.5 mmHg at 25°C
Index of Refraction	1.529
InChIKey	PYXFVCFISTUSOO-HKUCOEKDSA-N
SMILES	CC(C)=CCCC(C)(O)C1CCC2(C)C1C(O)CC1C3(C)CCC(O)C(C)(C)C3CCC12C

Safety Information

Hazard Codes	Xi

Synonyms

Protopanaxadiol

Protopanaxtriol

(20S)-Protopanaxadiol

20(S)-Protopanaxdiol

(3β,12β)-Dammar-24-ene-3,12,20-triol

PROTOPANAXDIOL

Dammar-24-ene-3,12,20-triol, (3β,12β)-

Protopanaxadiol, 20S-

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