CAS 434-16-2|(3β)-7-Dehydro Cholesterol
| Common Name | (3β)-7-Dehydro Cholesterol | ||
|---|---|---|---|
| CAS Number | 434-16-2 | Molecular Weight | 384.638 |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 493.7±34.0 °C at 760 mmHg |
| Molecular Formula | C27H44O | Melting Point | 148-152 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 212.3±17.9 °C |
Names
| Name | cholesta-5,7-dien-3β-ol |
|---|---|
| Synonym | More Synonyms |
(3β)-7-Dehydro Cholesterol BiologicalActivity
| Description | 7-Dehydrocholesterol is biosynthetic precursor of cholesterol and vitamin D3. |
|---|---|
| Related Catalog | Natural Products >>SteroidsResearch Areas >>Others |
| Target | Human Endogenous Metabolite |
| In Vitro | 7-Dehydrocholesterol is a biosynthetic precursor of cholesterol and vitamin D3. 7-Dehydrocholesterol is present in relatively high concentration in skin where it is converted to pre-vitamin D3 upon UV irradiation and where it is also exposed to exogenous radical sources and oxygen[1]. |
| References | [1]. Xu L, et al. Oxysterols from free radical chain oxidation of 7-dehydrocholesterol: product and mechanistic studies. J Am Chem Soc. 2010 Feb 24;132(7):2222-32. |
Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 493.7±34.0 °C at 760 mmHg |
| Melting Point | 148-152 °C(lit.) |
| Molecular Formula | C27H44O |
| Molecular Weight | 384.638 |
| Flash Point | 212.3±17.9 °C |
| Exact Mass | 384.339203 |
| PSA | 20.23000 |
| LogP | 9.46 |
| Vapour Pressure | 0.0±2.8 mmHg at 25°C |
| Index of Refraction | 1.536 |
| InChIKey | UCTLRSWJYQTBFZ-DDPQNLDTSA-N |
| SMILES | CC(C)CCCC(C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC21C |
| Storage condition | -20℃ |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 60 gm/kg/2W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application
- REFERENCE :
- NATWAY Naturwissenschaften. (Springer-Verlag, Heidelberger Platz 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1913- Volume(issue)/page/year: 60,525,1973
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | FZ5650000 |
Articles57
More Articles| Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium. PLoS ONE 4(4) , e5182, (2009) Activation of Hedgehog (Hh) signaling requires the transmembrane protein Smoothened (Smo), a member of the G-protein coupled receptor superfamily. In mammals, Smo translocates to the primary cilium up... | |
| Analysis of oxysterols and vitamin D metabolites in mouse brain and cell line samples by ultra-high-performance liquid chromatography-atmospheric pressure photoionization-mass spectrometry. J. Chromatogr. A. 1364 , 214-22, (2014) We have developed an ultra-high-performance liquid chromatography-atmospheric pressure photoionization-tandem mass spectrometric (UHPLC-APPI-MS/MS) method for the simultaneous quantitative analyses of... | |
| The Essential Role of Cholesterol Metabolism in the Intracellular Survival of Mycobacterium leprae Is Not Coupled to Central Carbon Metabolism and Energy Production. J. Bacteriol. 197 , 3698-707, (2015) Mycobacterium leprae induces the formation of lipid droplets, which are recruited to pathogen-containing phagosomes in infected macrophages and Schwann cells. Cholesterol is among the lipids with incr... |
Synonyms
| delta7-Cholesterol |
| (3b)-7-Dehydrocholesterol |
| Cholesta-5,7-dien-3-ol, (3β)- |
| Cholesta-5,7-dien-3β-ol (8CI) |
| Cholesta-5,7-dien-3-β-ol |
| Provitamin D3 |
| EINECS 207-100-5 |
| Dehydrocholesterol |
| (3Beta)-7-Dehydro Cholesterol |
| (3b)-Cholesta-5,7-dien-3-ol |
| 3β-Hydroxy-5,7-cholestadiene |
| Provitamine |
| cholesta-5,7-dien-3beta-ol |
| (-)-7-dehydrocholesterol |
| Dehydrocholesterin |
| (3β)-Cholesta-5,7-dien-3-ol |
| 5,7-Cholestadien-3β-ol |
| 7-DHC |
| 7-Dehydrocholesterol |
| Provitamin D(sub 3) |
| MFCD00003624 |
| Cholesta-5,7-dien-3β-ol |
| cholesta-5,7-dien-3b-ol |
| (3β)-7-Dehydrocholesterol |
