CAS 141497-12-3|H-Gly-Pro-Gly-NH2 · HCl
Introduction：Basic information about CAS 141497-12-3|H-Gly-Pro-Gly-NH2 · HCl, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | H-Gly-Pro-Gly-NH2 · HCl | ||
|---|---|---|---|
| CAS Number | 141497-12-3 | Molecular Weight | 264.70900 |
| Density | / | Boiling Point | / |
| Molecular Formula | C9H17ClN4O3 | Melting Point | / |
| MSDS | USA | Flash Point | / |
Names
| Name | h-gly-pro-gly-nh2 hcl |
|---|---|
| Synonym | More Synonyms |
H-Gly-Pro-Gly-NH2 · HCl BiologicalActivity
| Description | H-Gly-Pro-Gly-NH2 is a tripeptide that inhibits HIV-1 replication. H-Gly-Pro-Gly-NH2 inhibits the activity of HIV-1 IIIB and HIV-2 ROD with EC50 values of 35 µM and 30 µM, respectively. H-Gly Pro Gly NH2 inhibits HIV-1 replication in vitro by interfering with capsid formation. H-Gly Pro Gly NH2 has antiviral activity and can be used for virus research[1][2][3]. |
|---|---|
| Related Catalog | Signaling Pathways >>Anti-infection >>HIVResearch Areas >>Infection |
| Target | HIV (IIIB):35 μM (EC50) HIV-2 (ROD):30 μM (EC50) |
| In Vitro | H-Gly-Pro-Gly-NH2 (5、20 和 100 µM) 在感染 HIV-1 SF-2 的 HUT78 细胞中显示抗病毒活性[1]。 H-Gly-Pro-Gly-NH2 (100 µM) 在 ACH-2 细胞中破坏 HIV-1 病毒粒子的衣壳[1]。 H-Gly-Pro-Gly-NH2 对临床 HIV-1 的抗病毒活性[2] T215Y/F K70R M184V L74V T69D Mean IC50 (µM) 16 17 20 12 17 K103N Y181C G48V L90M V82A/T M46I/L Mean IC50 (µM) 13 21 16 18 16 17 |
| References | [1]. Höglund S, et al. Tripeptide interference with human immunodeficiency virus type 1 morphogenesis. Antimicrob Agents Chemother. 2002 Nov;46(11):3597-605. [2]. Andersson E, et al. No cross-resistance or selection of HIV-1 resistant mutants in vitro to the antiretroviral tripeptide glycyl-prolyl-glycine-amide[J]. Antiviral research, 2004, 61(2): 119-124. [3]. Balzarini J, et al. Obligatory involvement of CD26/dipeptidyl peptidase IV in the activation of the antiretroviral tripeptide glycylprolylglycinamide (GPG-NH(2)). Int J Biochem Cell Biol. 2004 Sep;36(9):1848-59. |
Chemical & Physical Properties
| Molecular Formula | C9H17ClN4O3 |
|---|---|
| Molecular Weight | 264.70900 |
| Exact Mass | 264.09900 |
| PSA | 118.52000 |
| LogP | 0.06900 |
| InChIKey | JWWLMJFURJYNEX-LURJTMIESA-N |
| SMILES | NCC(=O)N1CCCC1C(=O)NCC(N)=O |
Synonyms
| H-Gly-Pro-Gly-NH2 |
