Introduction：Basic information about CAS 110140-89-1|Ridogrel, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ridogrel |
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| CAS Number | 110140-89-1 | Molecular Weight | 366.33400 |
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| Density | 1.26g/cm3 | Boiling Point | 495.2ºC at 760mmHg |
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| Molecular Formula | C18H17F3N2O3 | Melting Point | / |
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| MSDS | / | Flash Point | 253.3ºC |
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Names
| Name | Pentanoic acid, 5-[[(E)-[3-pyridinyl[3-(trifluoromethyl)phenyl]methylene]amino]oxy] |
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| Synonym | More Synonyms |
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Ridogrel BiologicalActivity
| Description | Ridogrel (R 68070) is an orally active combined thromboxane A2 synthetase inhibitor and thromboxane A2/prostaglandin endoperoxide receptor blocker. Ridogrel is potent antiplatelet agent. Anti-inflammatory activities[1][2][3]. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Prostaglandin ReceptorResearch Areas >>Inflammation/Immunology |
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| In Vitro | In rats, R 68 070 (1.25 mg/kg orally, -2 h) singly prolongs tail bleeding times as much as a combination of TXA2 synthetase inhibition (dazoxiben 10 mg/kg) and TXA2/prostaglandin endoperoxide receptor blockade (BM 13177 40 mg/kg). In dogs, the compound reduces coronary thrombosis induced by electrical damage (1.25 mg/kg i.v.) and prevents the evolution of occlusion/reperfusion-induced arrhythmias into ventricular fibrillation (2.5 mg/kg i.v.)[2. |
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| References | [1]. De Clerck F, et al. R 68 070: thromboxane A2 synthetase inhibition and thromboxane A2/prostaglandin endoperoxide receptor blockade combined in one molecule--II. Pharmacological effects in vivo and ex vivo. Thromb Haemost. 1989;61(1):43-49. [2]. Di Perri T, et al. Ridogrel, una nuova molecula antiaggregante piastrinica a doppio meccanismo d'azione. Profilo farmacologico e clinico [Ridogrel, a new platelet antiaggregant molecule with a double mechanism of action. A pharmacological and clinical profile]. Recenti Prog Med. 1991;82(10):533-540. [3]. Carty E, et al. Ridogrel, a dual thromboxane synthase inhibitor and receptor antagonist: anti-inflammatory profile in inflammatory bowel disease. Aliment Pharmacol Ther. 2000;14(6):807-817. |
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Chemical & Physical Properties
| Density | 1.26g/cm3 |
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| Boiling Point | 495.2ºC at 760mmHg |
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| Molecular Formula | C18H17F3N2O3 |
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| Molecular Weight | 366.33400 |
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| Flash Point | 253.3ºC |
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| Exact Mass | 366.11900 |
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| PSA | 71.78000 |
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| LogP | 4.12430 |
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| Vapour Pressure | 1.26E-10mmHg at 25°C |
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| Index of Refraction | 1.531 |
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| InChIKey | GLLPUTYLZIKEGF-HAVVHWLPSA-N |
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| SMILES | O=C(O)CCCCON=C(c1cccnc1)c1cccc(C(F)(F)F)c1 |
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Synonyms
