CAS 146724-82-5|NOC-5
| Common Name | NOC-5 | ||
|---|---|---|---|
| CAS Number | 146724-82-5 | Molecular Weight | 176.217 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 270.1±42.0 °C at 760 mmHg |
| Molecular Formula | C6H16N4O2 | Melting Point | / |
| MSDS | USA | Flash Point | 117.2±27.9 °C |
Names
| Name | 3-[2-Hydroxy-1-(1-Methylethyl)-2-Nitrosohydrazino]-1-Propanamine Discontinued |
|---|---|
| Synonym | More Synonyms |
NOC-5 BiologicalActivity
| Description | NOC-5 is a diazeniumdiolate compound that belongs to the same family of NO donors[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
| In Vitro | NOC-5 (5-20 μM) in PBS led to a rapid increase in NO release on day one[1]. NOC-5 (100 μM, 24 h) activates only caspase-3; an increase in caspase-3 activity occurred after NO donor treatment: 1.62 (1.57-1.66) (P < 0.05). NOC-5 has pro-apoptotic action in Jurkat cells, but at the same time increased the level of anti-apoptotic proteins[2]. |
| References | [1]. Sophie A Bradley, et al. Characterisation and comparison of temporal release profiles of nitric oxide generating donors. J Neurosci Methods. 2015 Apr 30;245:116-24. [2]. Elena G Starikova, et al. Nitric oxide donor NOC-5 increases XIAP and Aven level in Jurkat cells. Cell Biol Int. 2014 Jul;38(7):799-802. |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 270.1±42.0 °C at 760 mmHg |
| Molecular Formula | C6H16N4O2 |
| Molecular Weight | 176.217 |
| Flash Point | 117.2±27.9 °C |
| Exact Mass | 176.127319 |
| PSA | 90.60000 |
| LogP | 0.02 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.525 |
| InChIKey | MTIRIKBRVALRPJ-NTMALXAHSA-N |
| SMILES | CC(C)N(CCCN)[N+]([O-])=NO |
Safety Information
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26;S36 |
| RIDADR | NONH for all modes of transport |
Articles3
More Articles| The seed of the Amazonian fruit Couepia bracteosa exhibits higher scavenging capacity against ROS and RNS than its shell and pulp extracts. Food Funct. 6 , 3081-90, (2015) Among the large number of scientifically unstudied fruits from the Amazonia biome, Couepia bracteosa acts as an interesting source of bioactive compounds, such as phenolic compounds and carotenoids, w... | |
| Influence of coffee genotype on bioactive compounds and the in vitro capacity to scavenge reactive oxygen and nitrogen species. J. Agric. Food Chem. 63 , 4815-26, (2015) The influence of green coffee genotype on the bioactive compounds and the in vitro antioxidant capacity against the principal reactive oxygen (ROO(•), H2O2, HO(•), and HOCl) and nitrogen (NO(•) and ON... | |
| Hrabie, J.A., et al. J. Org. Chem. 58 , 1472, (1993) |
Synonyms
| N-[3-aminopropyl(propan-2-yl)amino]-N-hydroxynitrous amide |
| 3-(Aminopropyl)-1-hydroxy-3-isopropyl-2-oxo-1-triazene |
| 1-(3-Aminopropyl)-2-hydroxy-1-isopropyl-3-oxotriazane |
| 1-Propanamine, 3-[2-hydroxy-1-(1-methylethyl)-3-oxotriazanyl]- |
| 3-(2-Hydroxy-1-(1-methylethyl)-2-nitrosohydrazino)-1-propanamine |
| MFCD00274389 |
