CAS 146724-86-9|MAHMA NONOate
Introduction：Basic information about CAS 146724-86-9|MAHMA NONOate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | MAHMA NONOate | ||
|---|---|---|---|
| CAS Number | 146724-86-9 | Molecular Weight | 204.270 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 301.7±44.0 °C at 760 mmHg |
| Molecular Formula | C8H20N4O2 | Melting Point | 102-108ºC |
| MSDS | ChineseUSA | Flash Point | 136.3±28.4 °C |
Names
| Name | mahma nonoate |
|---|---|
| Synonym | More Synonyms |
MAHMA NONOate BiologicalActivity
| Description | MAHMA NONOate is a NO donor. MAHMA NONOate effectively inhibits platelet aggregation induced by either collagen or ADP[1]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular Disease |
| In Vitro | MAHMA NONOate (0.1 nM-100 μM) dose-dependently inhibits platelet aggregation induced by either collagen or ADP[1]. MAHMA NONOate shows inhibitory effects to pulmonary artery and platelet aggregation with log IC50 values of 7.18 and 6.16, respectively[1]. |
| In Vivo | MAHMA NONOate (0.3-10 nmol/kg/min; i.v. once) shows both platelet inhibitory and vasodepressor effects in vivo[2]. Animal Model: Male Wistar rats anaesthetised with pentobarbitone[2] Dosage: 0.3-10 nmol/kg/min Administration: Intravenous injection; 0.3-10 nmol/kg/min once Result: Dose-dependently decreased in mean systemic artery pressure and showd a more potent effect than GSNO. Caused dose-dependent inhibition of the response to 0.3 μM/kg ADP. |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 301.7±44.0 °C at 760 mmHg |
| Melting Point | 102-108ºC |
| Molecular Formula | C8H20N4O2 |
| Molecular Weight | 204.270 |
| Flash Point | 136.3±28.4 °C |
| Exact Mass | 204.158630 |
| PSA | 68.17000 |
| LogP | 0.44 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.503 |
| Storage condition | 20°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | S24/25 |
| RIDADR | NONH for all modes of transport |
Articles25
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| Organelle-Specific Nitric Oxide Detection in Living Cells via HaloTag Protein Labeling. PLoS ONE 10 , e0123986, (2015) Nitric oxide (NO) is a membrane-permeable signaling molecule that is constantly produced, transferred, and consumed in vivo. NO participates and plays important roles in multiple biological processes.... | |
| Effect of nitric oxide on VnfA, a transcriptional activator of VFe-nitrogenase in Azotobacter vinelandii. J. Biochem. 157 , 365-75, (2015) The transcriptional activator, VnfA, is necessary for the expression of the structural genes encoding vanadium-dependent nitrogenase in Azotobacter vinelandii. We have previously reported that VnfA ha... |
Synonyms
| MFCD01310509 |
| METHYLAMINE HEXAMETHYLENE METHYLAMINE NONOATE |
| noc-9crystalline |
| 2-Hydroxy-1-methyl-1-[6-(methylamino)hexyl]-3-oxotriazane |
| 6-(2-Hydroxy-1-methyl-2-nitrosohydrazino)-N-methyl-1-hexanamine NOC-9 |
| 1-Hexanamine, 6-(2-hydroxy-1-methyl-3-oxotriazanyl)-N-methyl- |
| NOC-9 |
| MAHMA/NO |
