Introduction：Basic information about CAS 1949-89-9|2-Deoxy-D-lyxo-hexose, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 2-Deoxy-D-lyxo-hexose |
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| CAS Number | 1949-89-9 | Molecular Weight | 164.156 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 456.7±45.0 °C at 760 mmHg |
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| Molecular Formula | C6H12O5 | Melting Point | 107-110 °C(lit.) |
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| MSDS | / | Flash Point | 244.1±25.2 °C |
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Names
| Name | 2-deoxy-D-galactose |
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| Synonym | More Synonyms |
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2-Deoxy-D-lyxo-hexose BiologicalActivity
| Description | 2-Deoxy-D-galactose is a glucose analog. 2-Deoxy-D-galactose inhibits glycolysis to inhibits tumor growth. 2-Deoxy-D-galactose is a substance interfering with the fucosylation of glycomacromolecules and impairing memory consolidation in various learning tasks. 2-Deoxy-d-galactose hinders glycoprotein fucosylation in vivo[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease |
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| In Vitro | 2-Deoxy-D-galactose (1 mM/L; 5 h) is rapid phosphorylation during the first 30 min and decreases to approximately 20% of this rate during the subsequent hours in ascites hepatoma cells[4]. |
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| In Vivo | 2-Deoxy-D-galactose (380 mg/kg; i.p.; for 6 times) strongly decreases contents of UMP, UDPG, and UDP galactose in rat livers[1]. 2-Deoxy-D-galactose (2-8 μM; intracerebroventricularly injection; once) shows PAR impairment 30 min before the acquisition trial a dose of 4 μM and 15 min delay after do-gal administration[3]. Animal Model: Male adult Wistar rats with passive avoidance response (PAR) acquisition trial[3] Dosage: 2, 4 and 8 μM Administration: Intracerebroventricularly injection; 2-8 μM; once Result: Exhibited PAR disruption at a dose of 4 μM. |
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| References | [1]. Keppler DO, et al. The trapping of uridine phosphates by D-galactosamine. D-glucosamine, and 2-deoxy-D-galactose. A study on the mechanism of galactosamine hepatitis. Eur J Biochem. 1970 Dec;17(2):246-53. [2]. Krug M, et al. The amnesic substance 2-deoxy-D-galactose suppresses the maintenance of hippocampal LTP. Brain Res. 1991 Feb 1;540(1-2):237-42. [3]. Lorenzini CG, et al. 2-Deoxy-D-galactose effects on passive avoidance memorization in the rat. Neurobiol Learn Mem. 1997 Nov;68(3):317-24. [4]. Smith DF, Keppler DO. 2-Deoxy-D-galactose metabolism in ascites hepatoma cells results in phosphate trapping and glycolysis inhibition. Eur J Biochem. 1977 Feb 15;73(1):83-92. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 456.7±45.0 °C at 760 mmHg |
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| Melting Point | 107-110 °C(lit.) |
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| Molecular Formula | C6H12O5 |
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| Molecular Weight | 164.156 |
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| Flash Point | 244.1±25.2 °C |
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| Exact Mass | 164.068466 |
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| PSA | 90.15000 |
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| LogP | -3.07 |
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| Vapour Pressure | 0.0±2.5 mmHg at 25°C |
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| Index of Refraction | 1.534 |
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| InChIKey | VRYALKFFQXWPIH-HSUXUTPPSA-N |
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| SMILES | O=CCC(O)C(O)C(O)CO |
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Safety Information
| Hazard Codes | Xi: Irritant; |
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| Risk Phrases | 20/21/22-36/37/38 |
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| Safety Phrases | S24/25 |
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| WGK Germany | 3 |
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| HS Code | 2912491000 |
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Customs
| HS Code | 2912491000 |
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| Summary | 2912491000. other aldehyde-alcohols. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0% |
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Synonyms
| 2-DEOXY-D-LYXOHEXOSE |
| 2-deoxy-galactose |
| 2-deoxy-lyxo-hexose |
| 2-Deoxy-B-D-Lyxo-Hexose |
| EINECS 217-765-3 |
| Deoxygalactose |
| 2-Dexoy-D-Lyxohexose |
| D-2-Desoxygalactose |
| D-2-deoxygalactose |
| D-lyxo-Hexose, 2-deoxy- |
| 2-Deoxy-D-GalaCLose |
| D-lyxo-Hexose,2-deoxy |
| lyxo-Hexose, 2-deoxy- |
| 2-Deoxy-D-Galactopyranose |
| 2-Deoxy-D-galactose |
| MFCD00014649 |
| DEOXY-D-GALACTOSE,2 |
| 2-deoxy-D-talose |
| (3R,4R,5R)-3,4,5,6-Tetrahydroxyhexanal |
