Introduction：Basic information about CAS 671-95-4|clofenamide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | clofenamide |
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| CAS Number | 671-95-4 | Molecular Weight | 270.71 |
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| Density | 1.699g/cm3 | Boiling Point | 551.6ºC at 760 mmHg |
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| Molecular Formula | C6H7ClN2O4S2 | Melting Point | 206-207° (Davies); mp 217-219° (Olivier) |
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| MSDS | / | Flash Point | 287.4ºC |
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Names
| Name | 4-chlorobenzene-1,3-disulfonamide |
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| Synonym | More Synonyms |
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clofenamide BiologicalActivity
| Description | Clofenamide (Aquedux) is a carbonic anhydrase (CA) inhibitor. Clofenamide exhibits diuretic activity[1]. |
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| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Carbonic AnhydraseResearch Areas >>Metabolic Disease |
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| References | [1]. Delbeke FT, et, al. The influence of diuretics on the excretion and metabolism of doping agents. III. Etilamfetamine. Arzneimittelforschung. 1986 Sep;36(9):1413-6. |
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Chemical & Physical Properties
| Density | 1.699g/cm3 |
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| Boiling Point | 551.6ºC at 760 mmHg |
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| Melting Point | 206-207° (Davies); mp 217-219° (Olivier) |
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| Molecular Formula | C6H7ClN2O4S2 |
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| Molecular Weight | 270.71 |
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| Flash Point | 287.4ºC |
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| Exact Mass | 269.95400 |
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| PSA | 137.08000 |
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| LogP | 3.19700 |
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| Index of Refraction | 1.627 |
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| InChIKey | NENBAISIHCWPKP-UHFFFAOYSA-N |
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| SMILES | NS(=O)(=O)c1ccc(Cl)c(S(N)(=O)=O)c1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- CZ9100000
- CHEMICAL NAME :
- m-Benzenedisulfonamide, 4-chloro-
- CAS REGISTRY NUMBER :
- 671-95-4
- BEILSTEIN REFERENCE NO. :
- 2142672
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C6-H7-Cl-N2-O4-S2
- MOLECULAR WEIGHT :
- 270.72
- WISWESSER LINE NOTATION :
- ZSWR BG ESZW
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 340 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued. Volume(issue)/page/year: 9,119,1970
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 21,775,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 661 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 21,775,1979
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Safety Information
Customs
| HS Code | 2935009090 |
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| Summary | 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
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Synonyms
| Frictan |
| Eleklin |
| 4-chloro-benzene-1,3-disulfonic acid diamide |
| Aponiere |
| Indigatin |
| 4-Chlor-benzol-1,3-disulfonamid |
| Haflutan |
| Monochlorphenamide |
| 4-Chlor-benzol-1,3-disulfonsaeure-diamid |
| Diumide |
| 1-Chlor-2,4-bis-sulfamoyl-benzol |
| Clofenamide |
| Mahi |
| 4-chloro-benzene-1,3-disulfonamide |
| Aquedux |
