CAS 121204-87-3|(Ala1.3.11.15)-Endothelin-1 trifluoroacetate salt
| Common Name | (Ala1.3.11.15)-Endothelin-1 trifluoroacetate salt | ||
|---|---|---|---|
| CAS Number | 121204-87-3 | Molecular Weight | 2367.674 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 2391.5±65.0 °C at 760 mmHg |
| Molecular Formula | C109H163N25O32S | Melting Point | / |
| MSDS | USA | Flash Point | 1400.1±34.3 °C |
Names
| Name | [Ala1,3,11,15]-Endothelin |
|---|---|
| Synonym | More Synonyms |
BiologicalActivity
| Description | [Ala1,3,11,15]-Endothelin (53-63) is an ETB agonist. [Ala1,3,11,15]-Endothelin (53-63) has selectivity for ETB with IC50 values range from 0.33 nM to 0.61 nM. [Ala1,3,11,15]-Endothelin (53-63) can be used for the research of vasoconstriction[1][2]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseResearch Areas >>EndocrinologySignaling Pathways >>GPCR/G Protein >>Endothelin Receptor |
| Target | IC50 for ETB: 0.61 nM (Bronchus); 0.61 nM (Lung); 0.33 nM (Cerebellum); 2200 nM (VSMC)[1] |
| In Vitro | [Ala1,3,11,15]-Endothelin (53-63) (0.1 μM) has selectivity for ETB with IC50 values of 0.61 nM, 0.61 nM, 0.33 nM, 2200 nM in Bronchus, Lung, Cerebellum and VSMC, respectively[1]. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 2391.5±65.0 °C at 760 mmHg |
| Molecular Formula | C109H163N25O32S |
| Molecular Weight | 2367.674 |
| Flash Point | 1400.1±34.3 °C |
| Exact Mass | 2366.161621 |
| PSA | 933.93000 |
| LogP | 3.12 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.586 |
| Storage condition | −20°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles25
More Articles| Alterations in ET-1, not nitric oxide, in 1-week-old lambs with increased pulmonary blood flow. Am. J. Physiol. Heart Circ. Physiol. 284(2) , H480-90, (2003) Altered pulmonary vascular reactivity is a source of morbidity and mortality for children with congenital heart disease and increased pulmonary blood flow. Nitric oxide (NO) and endothelin (ET)-1 are ... | |
| Endothelin receptor blockade does not alter the increase in pulmonary blood flow due to oxygen ventilation in fetal lambs. Pediatr. Res. 40(1) , 152-7, (1996) At birth, pulmonary vasodilation occurs during rhythmic distension of the lungs with oxygen. Both mechanical and humoral factors are involved, including the release of vasoactive substances such as pr... | |
| Production of monocyte chemoattractant protein-1 and cytokine-induced neutrophil chemoattractant-1 in rat brain is stimulated by intracerebroventricular administration of an endothelin ETB receptor agonist. Neuroreport 18(12) , 1275-9, (2007) The role of endothelin (ET)B receptors in chemokine production in the brain of rats was examined. Intracerebroventricular administration of 500 pmol/day of Ala(1,3,11,15)-ET-1, a selective ETB agonist... |
Synonyms
| asasslmdkeavyfahldiiw |
| L-Tryptophan, L-alanyl-L-seryl-L-alanyl-L-seryl-L-seryl-L-leucyl-L-methionyl-L-α-aspartyl-L-lysyl-L-α-glutamyl-L-alanyl-L-valyl-L-tyrosyl-L-phenylalanyl-L-alanyl-L-histidyl-L-leucyl-L-α-as
 partyl-L-isoleucyl-L-isoleucyl- |
| ala-ser-ala-ser-ser-leu-met-asp-lys-glu-ala-val-tyr-phe-ala-his-leu-asp-ile-ile-trp |
| MFCD00143562 |
| L-Alanyl-L-seryl-L-alanyl-L-seryl-L-seryl-L-leucyl-L-methionyl-L-α-aspartyl-L-lysyl-L-α-glutamyl-L-alanyl-L-valyl-L-tyrosyl-L-phenylalanyl-L-alanyl-L-histidyl-L-leucyl-L-α-aspartyl-L-isole
 ucyl-L-isoleucyl-L-tryptophan |
| 4 ala et-1 |
