Introduction：Basic information about CAS 151057-13-5|L-701252, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | L-701252 |
|---|
| CAS Number | 151057-13-5 | Molecular Weight | 263.67600 |
|---|
| Density | 1.573g/cm3 | Boiling Point | 437.3ºC at 760mmHg |
|---|
| Molecular Formula | C13H10ClNO3 | Melting Point | / |
|---|
| MSDS | / | Flash Point | 218.3ºC |
|---|
Names
| Name | 7-chloro-3-(cyclopropanecarbonyl)-4-hydroxy-1H-quinolin-2-one |
|---|
| Synonym | More Synonyms |
|---|
L-701252 BiologicalActivity
| Description | L-701252 is a potent antagonist of glycine site NMDA receptor with an IC50 of 420 nM. L-701252 provides a small degree of neuroprotection in global cerebral ischaemia[1]. |
|---|
| Related Catalog | Signaling Pathways >>Neuronal Signaling >>iGluRResearch Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>iGluR |
|---|
| Target | NMDA receptor[1] |
|---|
| In Vivo | L-701252 (50 mg/kg; i.p.) provides a small non-significant protection[1]. Animal Model: 3-Months Male Mongolian gerbils (60 g)[1] Dosage: 50 mg/kg Administration: i.p. Result: Provided a small non-significant protection. |
|---|
| References | [1]. Stone TW. Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection. Trends Pharmacol Sci. 2000;21(4):149-154. [2]. Widdowson PS, et al. Failure of glycine site NMDA receptor antagonists to protect against L-2-chloropropionic acid-induced neurotoxicity highlights the uniqueness of cerebellar NMDA receptors. Brain Res. 1996;738(2):236-242. |
|---|
Chemical & Physical Properties
| Density | 1.573g/cm3 |
|---|
| Boiling Point | 437.3ºC at 760mmHg |
|---|
| Molecular Formula | C13H10ClNO3 |
|---|
| Molecular Weight | 263.67600 |
|---|
| Flash Point | 218.3ºC |
|---|
| Exact Mass | 263.03500 |
|---|
| PSA | 70.16000 |
|---|
| LogP | 2.47980 |
|---|
| Vapour Pressure | 2.03E-08mmHg at 25°C |
|---|
| Index of Refraction | 1.694 |
|---|
| InChIKey | MXEFWCFPCLDOOG-UHFFFAOYSA-N |
|---|
| SMILES | O=C(c1c(O)c2ccc(Cl)cc2[nH]c1=O)C1CC1 |
|---|
| Storage condition | -20°C |
|---|
Synonyms
