Introduction：Basic information about CAS 38090-53-8|TACA, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | TACA |
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| CAS Number | 38090-53-8 | Molecular Weight | 101.10400 |
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| Density | 1.169 g/cm3 | Boiling Point | 300.4ºC at 760 mmHg |
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| Molecular Formula | C4H7NO2 | Melting Point | >158°C (lit.) |
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| MSDS | USA | Flash Point | 135.5ºC |
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Names
| Name | trans-4-Aminocrotonicacid |
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| Synonym | More Synonyms |
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TACA BiologicalActivity
| Description | TACA (trans-4-Aminocrotonic acid) is a potent agonist of GABAA and GABAC receptors (KD= 0.6 μM). TACA also is GABA uptake inhibitor and substrate for GABA-T. TACA produces late biphasic responses in the MPG neurons[1][2][3]. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>GABA ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>GABA Receptor |
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| Target | KD: 0.6 μM (GABAC)[1]. |
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| In Vivo | TACA is a potent competitive inhibitor of GABA uptake in rat brain slices and thus is possibly a substrate for the GABA uptake system[3]. |
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| References | [1]. Chebib M, et al. Analogues of gamma-aminobutyric acid (GABA) and trans-4-aminocrotonic acid (TACA) substituted in the 2 position as GABAC receptor antagonists. Br J Pharmacol. 1997;122(8):1551-1560. [2]. Akasu T, et al. Role of GABAA and GABAC receptors in the biphasic GABA responses in neurons of the rat major pelvic ganglia. J Neurophysiol. 1999;82(3):1489-1496. [3]. Johnston GA, et al. Cis- and trans-4-aminocrotonic acid as GABA analogues of restricted conformation. J Neurochem. 1975;24(1):157-160. |
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Chemical & Physical Properties
| Density | 1.169 g/cm3 |
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| Boiling Point | 300.4ºC at 760 mmHg |
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| Melting Point | >158°C (lit.) |
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| Molecular Formula | C4H7NO2 |
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| Molecular Weight | 101.10400 |
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| Flash Point | 135.5ºC |
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| Exact Mass | 101.04800 |
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| PSA | 63.32000 |
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| LogP | 0.28620 |
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Safety Information
Synonyms
| MFCD00673818 |
| 4-Amino-trans-crotonsaeure |
| 4-amino-trans-crotonic acid |
| trans-4-Aminocrotonic acid,TACA |
| 4-amino-2-butenoic acid |
| trans-4-aminocrotonic acid |
