Introduction：Basic information about CAS 217082-60-5|[Pyr1] -Apelin 13, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | [Pyr1] -Apelin 13 |
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| CAS Number | 217082-60-5 | Molecular Weight | 1532.81 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C70H109N21O16S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | [Pyr1]-Apelin-13 |
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| Synonym | More Synonyms |
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[Pyr1] -Apelin 13 BiologicalActivity
| Description | [Pyr1]-Apelin-13 is a highly potent, selective endogenous apelin receptor (APJ) agonist. |
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| Related Catalog | Signaling Pathways >>Others >>OthersPeptidesResearch Areas >>Cardiovascular Disease |
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| In Vitro | [Pyr1]-apelin-13 encapsulation in lipoPEG particles (lipoPEG-PA13) results in sustained and extended drug release under physiological conditions[1]. |
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| In Vivo | [Pyr1]-apelin-13 nanocarriers in a mouse model of pressure-overload induced heart failure demonstrate a sustainable long-term effect of [Pyr1]-apelin-13 in preventing cardiac dysfunction[1]. [Pyr1] apelin-13 (1, 5 μg) improves locomotor activity and reduces pain symptoms, cavity size and caspase-3 levels in rats. [Pyr1] apelin-13 (1, 5 μg) significantly increases thermal paw withdrawal latency. [Pyr1] apelin-13 in 5 μg dose also produces significant attenuation in paw withdrawal threshold compared to SCI animals from the second week post SCI[2]. |
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| References | [1]. Serpooshan V, et al. [Pyr1]-Apelin-13 delivery via nano-liposomal encapsulation attenuates pressure overload-induced cardiac dysfunction. Biomaterials. 2015 Jan;37:289-98. [2]. Hajimashhadi Z, et al. Chronic administration of [Pyr1] apelin-13 attenuates neuropathic pain after compression spinal cord injury in rats. Neuropeptides. 2017 Feb;61:15-22. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Molecular Formula | C70H109N21O16S |
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| Molecular Weight | 1532.81 |
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| PSA | 613.26000 |
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| LogP | -3.42 |
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| Index of Refraction | 1.696 |
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| InChIKey | GGMAXEWLXWJGSF-PEWBXTNBSA-N |
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| SMILES | CSCCC(NC(=O)C1CCCN1C(=O)CNC(=O)C(CCCCN)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCC(=O)N1)C(=O)N1CCCC1C(=O)NC(Cc1ccccc1)C(=O)O |
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| Storage condition | -15°C |
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Synonyms
| PGLU-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE |
| pQRPRLSHKGPMPF |
| Deltorphin I |
| PYR-RPRLSHKGPMPF-OH |
| GLP-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE |
| 5-Oxo-L-prolyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-L-phenylalanine |
| L-Phenylalanine, 5-oxo-L-prolyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl- |
| PYR-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE |
| pyroglutamyl apelin-13 |
