CAS 704-00-7|1,2-Diacetylbenzene

Introduction：Basic information about CAS 704-00-7|1,2-Diacetylbenzene, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
4. Safety Information
5. Customs
6. Articles15
7. Synonyms

Common Name	1,2-Diacetylbenzene
CAS Number	704-00-7	Molecular Weight	162.18500
Density	110 C 0.1 mm Hg(lit.)	Boiling Point	110 °C0.1 mm Hg(lit.)
Molecular Formula	C₁₀H₁₀O₂	Melting Point	39-41 °C(lit.)
MSDS	Chinese	Flash Point	>230 °F

Names

Name	1-(2-acetylphenyl)ethanone
Synonym	More Synonyms

Chemical & Physical Properties

Density	110 C 0.1 mm Hg(lit.)
Boiling Point	110 °C0.1 mm Hg(lit.)
Melting Point	39-41 °C(lit.)
Molecular Formula	C₁₀H₁₀O₂
Molecular Weight	162.18500
Flash Point	>230 °F
Exact Mass	162.06800
PSA	34.14000
LogP	2.09180
Index of Refraction	1.519
InChIKey	LVQFKRXRTXCQCZ-UHFFFAOYSA-N
SMILES	CC(=O)c1ccccc1C(C)=O
Storage condition	2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KM5782637

CHEMICAL NAME :: Ethanone, 1,1'-(1,2-phenylene)bis-

CAS REGISTRY NUMBER :: 704-00-7

LAST UPDATED :: 199606

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H10-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 440 mg/kg/11W-I

TOXIC EFFECTS :: Peripheral Nerve and Sensation - recording from afferent nerve Peripheral Nerve and Sensation - recording from peripheral motor nerve

REFERENCE :: JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 11,261,1991

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 320 mg/kg/8W-I

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 12,343,1992

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	KM5782637
HS Code	29143900

Customs

HS Code	29143900

Articles15

New insights into mechanisms of gamma-diketone-induced axonopathy.

Neurochem. Res. 34(11) , 1919-23, (2009)

We analyzed the impact of axonopathy-inducing agents 1,2-diacetylbenzene (1,2-DAB) and 2,5-hexanedione (2,5-HD) on membrane-bound protein disulfide isomerase (mPDI) versus soluble PDI (sPDI), or PDI-f...

Axonopathy-inducing 1,2-diacetylbenzene forms adducts with motor and cytoskeletal proteins required for axonal transport.

Neurochem. Res. 32(12) , 2152-9, (2007)

The aromatic hydrocarbon 1,2-diacetylbenzene (1,2-DAB) is a protein-reactive gamma-diketone metabolite of the neurotoxic solvent 1,2-diethylbenzene (1,2-DEB). The effect of neurotoxic 1,2-DAB and its ...

Amino acid and protein targets of 1,2-diacetylbenzene, a potent aromatic gamma-diketone that induces proximal neurofilamentous axonopathy.

Toxicol. Appl. Pharmacol. 183(1) , 55-65, (2002)

The gamma-diketone analogs 1,2-diacetylbenzene (1,2-DAB) and 2,5-hexanedione (2,5-HD), but not the delta-diketone 1,3-diacetylbenzene (1,3-DAB) or the beta-diketone 2,4-hexanedione, induce neuropathol...

Synonyms

MFCD00008733

o-Diacetylbenzene

o-acetylacetophenone

EINECS 211-877-6

1,2-Diacetylbenzene

1,2-acetyl-benzene

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