Introduction：Basic information about CAS 14556-46-8|Bupranolol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Bupranolol |
|---|
| CAS Number | 14556-46-8 | Molecular Weight | 271.78300 |
|---|
| Density | 1.098g/cm3 | Boiling Point | 396.3ºC at 760mmHg |
|---|
| Molecular Formula | C14H22ClNO2 | Melting Point | / |
|---|
| MSDS | / | Flash Point | 193.5ºC |
|---|
Names
| Name | Bupranolol |
|---|
| Synonym | More Synonyms |
|---|
Bupranolol BiologicalActivity
| Description | Bupranolol is an orally active, competitive and non-selective β-adrenoceptor antagonist without intrinsic sympathomimetic activity[1]. |
|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorResearch Areas >>Inflammation/Immunology |
|---|
| Target | β-adrenoceptor |
|---|
| In Vitro | Bupranolol (1~3 μM) shifts isoprenaline-induced relaxation in the presence of 30 μM propranolol. Bupranolol acts as a competitive antagonist of isoprenaline-induced relaxation in the presence of 300 nM propranolol, with a pA2 value of 5.90. Bupranolol antagonizes β1- and β2-ARs with pA2 values of ≈9.0, and also antagonizes β3-AR with a pA2 value of 6.0[1]. |
|---|
| References | [1]. Chino D, et al. Pharmacological identification of β-adrenoceptor subtypes mediating isoprenaline-induced relaxation of guinea pig colonic longitudinal smooth muscle. J Smooth Muscle Res. 2018;54(0):13-27. [2]. Babu RJ, et al. Effect of cyclodextrins on the complexation and transdermal delivery of bupranolol through rat skin. Int J Pharm. 2004;271(1-2):155-165. |
|---|
Chemical & Physical Properties
| Density | 1.098g/cm3 |
|---|
| Boiling Point | 396.3ºC at 760mmHg |
|---|
| Molecular Formula | C14H22ClNO2 |
|---|
| Molecular Weight | 271.78300 |
|---|
| Flash Point | 193.5ºC |
|---|
| Exact Mass | 271.13400 |
|---|
| PSA | 41.49000 |
|---|
| LogP | 3.16710 |
|---|
| Vapour Pressure | 5.44E-07mmHg at 25°C |
|---|
| Index of Refraction | 1.522 |
|---|
| InChIKey | HQIRNZOQPUAHHV-UHFFFAOYSA-N |
|---|
| SMILES | Cc1ccc(Cl)c(OCC(O)CNC(C)(C)C)c1 |
|---|
Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- UA8430000
- CHEMICAL NAME :
- 2-Propanol, 1-(tert-butylamino)-3-(2-chloro-5-methylphenoxy)-
- CAS REGISTRY NUMBER :
- 14556-46-8
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C14-H22-Cl-N-O2
- MOLECULAR WEIGHT :
- 271.82
- WISWESSER LINE NOTATION :
- 1X1&1&M1YQ1OR BG E1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 45 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1022,1977
|
Safety Information
Customs
| HS Code | 2922509090 |
|---|
| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
|---|
Synonyms
