CAS 112901-68-5|Amifostine trihydrate

Introduction：Basic information about CAS 112901-68-5|Amifostine trihydrate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Amifostine trihydrate BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Articles30
7. Synonyms

Common Name	Amifostine trihydrate
CAS Number	112901-68-5	Molecular Weight	268.269
Density	1.367g/cm3	Boiling Point	441.7ºC at 760 mmHg
Molecular Formula	C₅H₂₁N₂O₆PS	Melting Point	/
MSDS	ChineseUSA	Flash Point	220.9ºC
Symbol	GHS07	Signal Word	Warning

Names

Name	2-(3-aminopropylamino)ethylsulfanylphosphonic acid,trihydrate
Synonym	More Synonyms

Amifostine trihydrate BiologicalActivity

Description	Amifostine trihydrate (WR2721 trihydrate) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine trihydrate selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine trihydrate is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine trihydrate protects cells from damage by scavenging oxygen-derived free radicals. Amifostine trihydrate reduces renal toxicity and has antiangiogenic action[1][2][3][4].
Related Catalog	Research Areas >>CancerSignaling Pathways >>Apoptosis >>MDM-2/p53Signaling Pathways >>Metabolic Enzyme/Protease >>HIF/HIF Prolyl-Hydroxylase
References	[1]. John R Kouvaris, et al. Amifostine: the first selective-target and broad-spectrum radioprotector. Oncologist. 2007 Jun;12(6):738-47. [2]. John R Kouvaris, et al. Amifostine: the first selective-target and broad-spectrum radioprotector. Oncologist. 2007 Jun;12(6):738-47. [3]. D Maurici, et al. Amifostine (WR2721) restores transcriptional activity of specific p53 mutant proteins in a yeast functional assay. Oncogene. 2001 Jun 14;20(27):3533-40. [4]. Efstathia Giannopoulou, et al. Amifostine inhibits angiogenesis in vivo. J Pharmacol Exp Ther. 2003 Feb;304(2):729-37. [5]. Michael I Koukourakis, et al. Amifostine induces anaerobic metabolism and hypoxia-inducible factor 1 alpha. Cancer Chemother Pharmacol. 2004 Jan;53(1):8-14.

Description

Amifostine trihydrate (WR2721 trihydrate) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine trihydrate selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine trihydrate is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine trihydrate protects cells from damage by scavenging oxygen-derived free radicals. Amifostine trihydrate reduces renal toxicity and has antiangiogenic action[1][2][3][4].

Related Catalog

Research Areas >>CancerSignaling Pathways >>Apoptosis >>MDM-2/p53Signaling Pathways >>Metabolic Enzyme/Protease >>HIF/HIF Prolyl-Hydroxylase

References

[1]. John R Kouvaris, et al. Amifostine: the first selective-target and broad-spectrum radioprotector. Oncologist. 2007 Jun;12(6):738-47.

[2]. John R Kouvaris, et al. Amifostine: the first selective-target and broad-spectrum radioprotector. Oncologist. 2007 Jun;12(6):738-47.

[3]. D Maurici, et al. Amifostine (WR2721) restores transcriptional activity of specific p53 mutant proteins in a yeast functional assay. Oncogene. 2001 Jun 14;20(27):3533-40.

[4]. Efstathia Giannopoulou, et al. Amifostine inhibits angiogenesis in vivo. J Pharmacol Exp Ther. 2003 Feb;304(2):729-37.

[5]. Michael I Koukourakis, et al. Amifostine induces anaerobic metabolism and hypoxia-inducible factor 1 alpha. Cancer Chemother Pharmacol. 2004 Jan;53(1):8-14.

Chemical & Physical Properties

Density	1.367g/cm3
Boiling Point	441.7ºC at 760 mmHg
Molecular Formula	C₅H₂₁N₂O₆PS
Molecular Weight	268.269
Flash Point	220.9ºC
Exact Mass	268.085785
PSA	158.38000
LogP	0.64900
Appearance of Characters	powder
Vapour Pressure	4.9E-09mmHg at 25°C
InChIKey	TXQPXJKRNHJWAX-UHFFFAOYSA-N
SMILES	NCCCNCCSP(=O)(O)O.O.O.O
Storage condition	2-8°C

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R22
Safety Phrases	26-36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	TE6491000
HS Code	2930909090

Customs

HS Code	2930909090
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles30

The zebrafish--Danio rerio--is a useful model for measuring the effects of small-molecule mitigators of late effects of ionizing irradiation.

In Vivo 26(6) , 889-97, (2012)

Use of zebrafish models may decrease the cost of screening new irradiation protectors and mitigators.Zebrafish (Danio rerio) models were tested for screening water-soluble radiation protectors and mit...

A Phase I Clinical and Pharmacology Study Using Amifostine as a Radioprotector in Dose-escalated Whole Liver Radiation Therapy

Int. J. Radiat. Oncol. Biol. Phys. 83(5) , 1441-7, (2012)

Purpose Diffuse intrahepatic tumors are difficult to control. Whole-liver radiotherapy has been limited by toxicity, most notably radiation-induced liver disease. Amifostine is a prodrug free-radical ...

The effect of Amifostine (Ethyol) on intestinal anastomosis in rats with radiation enteritis.

Eur. Rev. Med. Pharmacol. Sci. 17(10) , 1351-9, (2013)

Preoperative radiotherapy in colorectal cancers is being used as an adjuvant therapy with increasing frequency. Postoperative complications in early and late periods in various ratios are reported. It...

Synonyms

S-{2-[(3-Aminopropyl)amino]ethyl} dihydrogen phosphorothioate trihydrate

MFCD00233058

UNII-M487QF2F4V

WR-2721

Anifostine trihydrate

Ethanethiol, 2-[(3-aminopropyl)amino]-, dihydrogen phosphate (ester), hydrate (1:3)

Amifostine

Amifostine trihydrate

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