Introduction：Basic information about CAS 152-97-6|Fluocortolone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Fluocortolone |
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| CAS Number | 152-97-6 | Molecular Weight | 376.462 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 537.4±50.0 °C at 760 mmHg |
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| Molecular Formula | C22H29FO4 | Melting Point | 113-116ºC |
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| MSDS | / | Flash Point | 278.8±30.1 °C |
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Names
| Name | Fluocortolone |
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| Synonym | More Synonyms |
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Fluocortolone BiologicalActivity
| Description | Fluocortolone is an orally active anti-inflammatory agent that effectively reduces plasma fibrinogen levels. Fluocortolone inhibits Mycobacterium butyricum-induced foot edema in a rat model of adjuvanted joint inflammation (3-12 mg/kg)[1]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
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| References | [1]. Bhargava A S. Effect of anti-inflammatory agents on adjuvant-induced edema modified for primary test[J]. Pharmacological Research Communications, et al. Effect of anti-inflammatory agents on adjuvant-induced edema modified for primary test[J]. Pharmacological Research Communications, 1971, 3(1): 83-91. . |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 537.4±50.0 °C at 760 mmHg |
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| Melting Point | 113-116ºC |
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| Molecular Formula | C22H29FO4 |
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| Molecular Weight | 376.462 |
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| Flash Point | 278.8±30.1 °C |
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| Exact Mass | 376.204987 |
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| PSA | 74.60000 |
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| LogP | 1.86 |
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| Vapour Pressure | 0.0±3.2 mmHg at 25°C |
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| Index of Refraction | 1.572 |
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| InChIKey | GAKMQHDJQHZUTJ-ULHLPKEOSA-N |
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| SMILES | CC1CC2C3CC(F)C4=CC(=O)C=CC4(C)C3C(O)CC2(C)C1C(=O)CO |
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| Storage condition | 2~8°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- TU3832500
- CHEMICAL NAME :
- Pregna-1,4-diene-3,20-dione, 6-alpha-fluoro-11-beta,21-dihydroxy-16-alpha-methyl-
- CAS REGISTRY NUMBER :
- 152-97-6
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C22-H29-F-O4
- MOLECULAR WEIGHT :
- 376.51
- WISWESSER LINE NOTATION :
- L E5 B666 OV AHTTT&J A1 CQ E1 FV1Q G1 LF
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 70 mg/kg
- SEX/DURATION :
- female 12 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death
- REFERENCE :
- YKRYAH Yakubutsu Ryoho. Medicinal Treatment. (Tokyo, Japan) V.1-14, 1968-81. Suspended. Volume(issue)/page/year: 9,1623,1976
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 20 mg/kg
- SEX/DURATION :
- female 12 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- REFERENCE :
- YKRYAH Yakubutsu Ryoho. Medicinal Treatment. (Tokyo, Japan) V.1-14, 1968-81. Suspended. Volume(issue)/page/year: 9,1623,1976
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 70 mg/kg
- SEX/DURATION :
- female 13 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
- REFERENCE :
- YKRYAH Yakubutsu Ryoho. Medicinal Treatment. (Tokyo, Japan) V.1-14, 1968-81. Suspended. Volume(issue)/page/year: 9,1623,1976
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 70 mg/kg
- SEX/DURATION :
- female 13 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
- REFERENCE :
- YKRYAH Yakubutsu Ryoho. Medicinal Treatment. (Tokyo, Japan) V.1-14, 1968-81. Suspended. Volume(issue)/page/year: 9,1623,1976
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- DOSE :
- 2500 ug/kg
- SEX/DURATION :
- female 6-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
- REFERENCE :
- AMBED4 AMI-Berichte. (Berlin, Fed. Rep. Ger.) No. 1-2, 1978-82. Volume(issue)/page/year: (1),127,1988
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 30 mg/kg
- SEX/DURATION :
- female 7-18 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
- REFERENCE :
- YKRYAH Yakubutsu Ryoho. Medicinal Treatment. (Tokyo, Japan) V.1-14, 1968-81. Suspended. Volume(issue)/page/year: 10,151,1977
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Safety Information
| Hazard Codes | Xn |
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| HS Code | 2942000000 |
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Customs
Synonyms
| FLUORCORTOLONE |
| Pregna-1,4-diene-3,20-dione, 6-fluoro-11,21-dihydroxy-16-methyl-, (6α,11β,16α)- |
| SH-742 |
| 6a-Fluoro-16a-methyl-1-dehydrocorticosterone |
| Fluorocortolone |
| Fluocortolon |
| flucortolone |
| 6a-Fluoro-16a-methyl-D1,4-pregnadiene-11b,21-diol-3,20-dione |
| EINECS 205-811-5 |
| (6α,11β,16α)-6-Fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione |
| methylfluorodehydrocorticosterone |
| Fluocortolone |
