Introduction：Basic information about CAS 68252-19-7|Pirmenol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Pirmenol |
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| CAS Number | 68252-19-7 | Molecular Weight | 338.48600 |
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| Density | 1.046g/cm3 | Boiling Point | 499.6ºC at 760 mmHg |
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| Molecular Formula | C22H30N2O | Melting Point | / |
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| MSDS | / | Flash Point | 256ºC |
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Names
| Name | Pirmenol |
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| Synonym | More Synonyms |
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Pirmenol BiologicalActivity
| Description | Pirmenol is an orally active antiarrhythmic agent. Pirmenol inhibits IK.ACh (IC50: 0.1 μM) by blocking mAchR. Pirmenol can be used in the research of cardiovascular disease, such as atrial fibrillation[1][2][4]. |
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| Related Catalog | Signaling Pathways >>Neuronal Signaling >>mAChRResearch Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>mAChRSignaling Pathways >>Membrane Transporter/Ion Channel >>Potassium Channel |
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| Target | IC50: 0.1 μM (IK.ACh)[1] |
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| In Vitro | Pirmenol (1 μM) inhibits the IK.ACh induced by carbachol or intracellular loading of GTPg S in in atrial cells[1]. Pirmenol (5 μM) depresses the early part of the plateau and lengthened the final repolarization of the action potentials in ventricular myocytes[3]. Pirmenol (1 μM) prolongs the action potential duration at 90% repolarization in atrial muscles and Purkinje fibers[3]. |
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| In Vivo | Pirmenol (2.5 and 5 mg/kg, p.o.) is effective against the arrhythmias in conscious, coronary artery ligated dogs[4]. Pirmenol (rats) shows LD50s of 359.9 mg/kg (p.o), 23.6 mg/kg (i.v.)[2]. Pirmenol (mice) shows LD50s of 215.5 mg/kg (p.o), 20.8 mg/kg (i.v.)[2]. Animal Model: Conscious, coronary artery ligated dogs[4] Dosage: Oral administration (p.o.) Administration: 2.5 and 5 mg/kg Result: Restored normal sinus rhythm, and showed a long duration of activity, wide safety margin. |
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Chemical & Physical Properties
| Density | 1.046g/cm3 |
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| Boiling Point | 499.6ºC at 760 mmHg |
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| Molecular Formula | C22H30N2O |
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| Molecular Weight | 338.48600 |
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| Flash Point | 256ºC |
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| Exact Mass | 338.23600 |
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| PSA | 36.36000 |
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| LogP | 4.29850 |
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| Index of Refraction | 1.547 |
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| InChIKey | APUDBKTWDCXQJA-QIDMFYOTSA-N |
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| SMILES | CC1CCCC(C)N1CCCC(O)(c1ccccc1)c1ccccn1 |
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Synonyms
| 2-Pyridinemethanol,a-[3-[(2R,6S)-2,6-dimethyl-1-piperidinyl]propyl]-a-phenyl-,rel-(9CI) |
| 2-Pyridinemethanol,a-[3-(2,6-dimethyl-1-piperidinyl)propyl]-a-phenyl-,cis-(+-) |
| 4-[(2S,6R)-2,6-dimethylpiperidin-1-yl]-1-phenyl-1-pyridin-2-ylbutan-1-ol |
