CAS 99-85-4|γ-terpinene

Introduction：Basic information about CAS 99-85-4|γ-terpinene, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. γ-terpinene BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles29
8. Synonyms

Common Name	γ-terpinene
CAS Number	99-85-4	Molecular Weight	136.234
Density	0.8±0.1 g/cm3	Boiling Point	183.0±0.0 °C at 760 mmHg
Molecular Formula	C₁₀H₁₆	Melting Point	60-61ºC
MSDS	ChineseUSA	Flash Point	51.7±0.0 °C
Symbol	GHS02, GHS07	Signal Word	Warning

Names

Name	γ-terpinene
Synonym	More Synonyms

γ-terpinene BiologicalActivity

Description	γ-Terpinene, a monoterpene, is an orally active antioxidant compound which can scavenge radicals directly. γ-Terpinene has potent antinociception activity[1].
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease
In Vivo	γ-Terpinene (γ-TPN; 12.5, 25 mg/kg; p.o.; single dose) significantly reduces the licking time of the stimulated paw in both phases of the test in male Swiss mice (20-30 g)[1]. γ-Terpinene given either systemically (p.o.; 1.56, 3.125, and 6.25 mg/kg) or centrally (i.t or i.c.v; 10 and 20 μg/site) causes significant inhibition of glutamate-induced nociception in mice[1].
References	[1]. Flávia Franceli de Brito Passos, et al. Involvement of Cholinergic and Opioid System in γ-Terpinene-Mediated Antinociception. Evid Based Complement Alternat Med. 2015;2015:829414. [2]. Guo-Xiang Li, et al. Unusual antioxidant behavior of alpha- and gamma-terpinene in protecting methyl linoleate, DNA, and erythrocyte. J Agric Food Chem. 2009 May 13;57(9):3943-8.

Chemical & Physical Properties

Density	0.8±0.1 g/cm3
Boiling Point	183.0±0.0 °C at 760 mmHg
Melting Point	60-61ºC
Molecular Formula	C₁₀H₁₆
Molecular Weight	136.234
Flash Point	51.7±0.0 °C
Exact Mass	136.125198
LogP	4.36
Vapour density	4.7 (vs air)
Vapour Pressure	1.1±0.2 mmHg at 25°C
Index of Refraction	1.476
InChIKey	YKFLAYDHMOASIY-UHFFFAOYSA-N
SMILES	CC1=CCC(C(C)C)=CC1
Storage condition	2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OS8070000

CHEMICAL NAME :: p-Mentha-1,4-diene

CAS REGISTRY NUMBER :: 99-85-4

LAST UPDATED :: 199709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H16

MOLECULAR WEIGHT :: 136.26

WISWESSER LINE NOTATION :: L6U CUTJ AY1&1 D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 14,875,1976 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3650 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 14,875,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5192 No. of Facilities: 1436 (estimated) No. of Industries: 29 No. of Occupations: 26 No. of Employees: 35259 (estimated) No. of Female Employees: 6925 (estimated)

Safety Information

Symbol	GHS02, GHS07
Signal Word	Warning
Hazard Statements	H226-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xi: Irritant;
Risk Phrases	R10;R36/37/38
Safety Phrases	S26-S36
RIDADR	UN 2319 3/PG 3
WGK Germany	2
RTECS	OS8070000
Packaging Group	III
Hazard Class	3.2
HS Code	2902199090

Customs

HS Code	2902199090
Summary	2902199090 other cyclanes, cyclenes and cyclotherpenes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%

Articles29

Distribution of primary and specialized metabolites in Nigella sativa seeds, a spice with vast traditional and historical uses.

Molecules 17(9) , 10159-77, (2012)

Black cumin (Nigella sativa L., Ranunculaceae) is an annual herb commonly used in the Middle East, India and nowadays gaining worldwide acceptance. Historical and traditional uses are extensively docu...

Antimicrobial and antioxidant activities of essential oils of Satureja thymbra growing wild in Libya.

Molecules 17(5) , 4836-50, (2012)

The composition of essential oil isolated from Satureja thymbra, growing wild in Libya, was analyzed by GC and GC-MS. The essential oil was characterized by γ-terpinene (39.23%), thymol (25.16%), p-cy...

Variation of volatiles in Tunisian populations of Thymbra capitata (L.) Cav. (Lamiaceae).

Chem. Biodivers. 9(7) , 1272-85, (2012)

Volatiles from 14 wild Tunisian populations of Thymbra capitata (=Thymus capitatus Hoffmanns. et Link=Coridothymus capitatus Rchb.f.), sampled in five ecological areas (sub-humid, upper semi-arid, mea...

Synonyms

Terpinene

1-Isopropyl-4-methyl-1,4-cyclohexadiene

MFCD00001537

1-methyl-4-propan-2-ylcyclohexa-1,4-diene

gamma-terpinene

1,4-p-Menthadiene

γ-terpinene

1-Methyl-4-isopropyl-1,4-cyclohexadiene

1,4-Cyclohexadiene, 1-methyl-4-(1-methylethyl)-

1-Methyl-4-(propan-2-yl)cyclohexa-1,4-diene

g-Terpinene

p-Mentha-1,4-diene

1-Isopropyl-4-methylcyclohexa-1,4-diene

EINECS 202-794-6

Recommended......