CAS 59468-85-8|8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-4-ol
Introduction：Basic information about CAS 59468-85-8|8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-4-ol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-4-ol | ||
|---|---|---|---|
| CAS Number | 59468-85-8 | Molecular Weight | 341.76700 |
| Density | 1.44g/cm3 | Boiling Point | 550.6ºC at 760 mmHg |
| Molecular Formula | C18H13ClFN3O | Melting Point | 186-187ºC |
| MSDS | USA | Flash Point | 286.8ºC |
Names
| Name | 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-4-ol |
|---|---|
| Synonym | More Synonyms |
Chemical & Physical Properties
| Density | 1.44g/cm3 |
|---|---|
| Boiling Point | 550.6ºC at 760 mmHg |
| Melting Point | 186-187ºC |
| Molecular Formula | C18H13ClFN3O |
| Molecular Weight | 341.76700 |
| Flash Point | 286.8ºC |
| Exact Mass | 341.07300 |
| PSA | 50.41000 |
| LogP | 3.25070 |
| Index of Refraction | 1.688 |
| InChIKey | ZYISITHKPKHPKG-UHFFFAOYSA-N |
| SMILES | Cc1ncc2n1-c1ccc(Cl)cc1C(c1ccccc1F)=NC2O |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
Articles30
More Articles| A comparison of the metabolism of midazolam in C57BL/6J and hepatic reductase null (HRN) mice. Biochem. Pharmacol. 92(4) , 701-11, (2014) The hepatic cytochrome P450 reductase null (HRN) mouse, which has no functional hepatic Cyp P450s, may represent a useful model for examining extra-hepatic P450-related oxidative metabolism. Here the ... | |
| Systematic evaluation of commercially available ultra-high performance liquid chromatography columns for drug metabolite profiling: optimization of chromatographic peak capacity. J. Chromatogr. A. 1374 , 122-33, (2014) The present study investigated the practical use of modern ultra-high performance liquid chromatography (UHPLC) separation techniques for drug metabolite profiling, aiming to develop a widely applicab... | |
| Species differences and substrate specificity of CYP3A heteroactivation by efavirenz. Xenobiotica 45(4) , 345-52, (2015) 1. The purpose of this study was to clarify species differences in the heteroactivation of CYP3A substrates by efavirenz, which is known from clinical studies to activate midazolam 1'-hydroxylation, a... |
Synonyms
| 8-Chloro-6-(2-fluorophenyl)-4-hydroxy-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine |
| 8-Chloro-6-(2-fluorophenyl)-4-hydroxy-4H-imidazo[1,5a][1,4]bezodiazepine |
| 4-OH-Mdz |
| 4-hydroxy-MDZ |
| 8-chloro-(2-fluoro-phenyl)-1-methyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-4-ol |
| 4-Hydroxy Midazolam |
