CAS 68528-80-3|DSS Crosslinker
| Common Name | DSS Crosslinker | ||
|---|---|---|---|
| CAS Number | 68528-80-3 | Molecular Weight | 368.339 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 513.5±60.0 °C at 760 mmHg |
| Molecular Formula | C16H20N2O8 | Melting Point | 169-170ºC |
| MSDS | ChineseUSA | Flash Point | 264.4±32.9 °C |
Names
| Name | disuccinimidyl suberate |
|---|---|
| Synonym | More Synonyms |
DSS Crosslinker BiologicalActivity
| Description | DSS Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC Linker |
| Target | Non-cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. |
| References | [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 513.5±60.0 °C at 760 mmHg |
| Melting Point | 169-170ºC |
| Molecular Formula | C16H20N2O8 |
| Molecular Weight | 368.339 |
| Flash Point | 264.4±32.9 °C |
| Exact Mass | 368.121979 |
| PSA | 127.36000 |
| LogP | -2.24 |
| Appearance of Characters | powder |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.555 |
| InChIKey | ZWIBGKZDAWNIFC-UHFFFAOYSA-N |
| SMILES | O=C(CCCCCCC(=O)ON1C(=O)CCC1=O)ON1C(=O)CCC1=O |
| Storage condition | 2-8°C |
| Water Solubility | chloroform: 50 mg/mL | Insoluble in water. Soluble in chloroform: 50 mg/mL. |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | 24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 29171900 |
Articles85
More Articles| Stability of structured Kaposi's sarcoma-associated herpesvirus ORF57 protein is regulated by protein phosphorylation and homodimerization. J. Virol. 89(6) , 3256-74, (2015) Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 plays an essential role in KSHV lytic infection by promoting viral gene expression at the posttranscriptional level. Using bioinformatic and bioche... | |
| Proteasome assembly from 15S precursors involves major conformational changes and recycling of the Pba1-Pba2 chaperone. Nat. Commun. 6 , 6123, (2015) The chaperones Ump1 and Pba1-Pba2 promote efficient biogenesis of 20S proteasome core particles from its subunits via 15S intermediates containing alpha and beta subunits, except beta7. Here we elucid... | |
| Morphine-induced internalization of the L83I mutant of the rat μ-opioid receptor. Br. J. Pharmacol. 172(2) , 593-605, (2014) Naturally occurring single-nucleotide polymorphisms (SNPs) within GPCRs can result in alterations in various pharmacological parameters. Understanding the regulation and function of endocytic traffick... |
Synonyms
| 1,1'-((1,8-Dioxo-1,8-octanediyl)bis(oxy))bis-2,5-pyrrolidinedione |
| 1,1'-[(1,8-Dioxo-1,8-octanediyl)bis(oxy)]di(2,5-pyrrolidinedione) |
| Di(N-succinimidyl) Suberate |
| 2,5-Pyrrolidinedione, 1,1'-((1,8-dioxo-1,8-octanediyl)bis(oxy))bis- |
| Disuccinimidyl octanedioate |
| Suberic acid bis(N-succinimidyl) ester |
| MFCD00049059 |
| 1,1'-[(1,8-Dioxooctane-1,8-diyl)bis(oxy)]dipyrrolidine-2,5-dione |
| Disuccinimidyl suberate |
| Suberic acid bis(N-hydroxysuccinimide ester) |
| 2,5-Pyrrolidinedione, 1,1'-[(1,8-dioxo-1,8-octanediyl)bis(oxy)]bis- |
