Introduction：Basic information about CAS 571-31-3|Androstan-17-one,3-hydroxy-, (3b,5b)-, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Androstan-17-one,3-hydroxy-, (3b,5b)- |
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| CAS Number | 571-31-3 | Molecular Weight | 290.44000 |
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| Density | 1.085 g/cm3 | Boiling Point | 413.1ºC at 760 mmHg |
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| Molecular Formula | C19H30O2 | Melting Point | 154-156ºC |
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| MSDS | / | Flash Point | 176.4ºC |
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Names
| Name | (3S,5R,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-one |
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| Synonym | More Synonyms |
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Androstan-17-one,3-hydroxy-, (3b,5b)- BiologicalActivity
| Description | 5β-Androstan-3β-ol-17-one (3β-Etiocholanolone; 5β-Epiandrosterone), a steroid with 5β reduction, is one the major metabolic products of ehydroepiandrosterone (DHEA). 5β-Androstan-3β-ol-17-one exert strong antihyperglycemic effects in C57BL/KsJ genetically diabetic (db/db) mice. 5β-Androstan-3β-ol-17-one also exerts depressive effect on neurons[1][2]. |
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| Related Catalog | Research Areas >>Metabolic DiseaseResearch Areas >>Neurological Disease |
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| In Vivo | 5β-Androstan-3β-ol-17-one (2 mg/mouse; 皮下注射; 每天 1 次, 共 4 周) 缺乏任何有益的影响，这表明这些代谢物需要一些生物转化才能完全有效[1]。 5β-Androstan-3β-ol-17-one (添加饲料中, 质量比分别为 0.025%, 0.05%, 0.1%; 口服; 共 18 周) 在小鼠中，防止严重糖尿病的发生，调节高血糖状态正常化，同时对进食量或体重增加率无影响[1]。 5β-Androstan-3β-ol-17-one (1 mg/kg-20 mg/kg; 静脉注射; 单剂量) 在高剂量下，对成年公猫的神经元有强烈的抑制作用[2]。 Animal Model: C57BL/KsJ genetically diabetic (db/db) mice model[1] Dosage: 0.025%, 0.05%, 0.1% in diet Administration: Oral gavage; filled the diet every second day; for 18 weeks Result: Exerted strong antihyperglycemic effects. |
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| References | [1]. Coleman DL, et al. Therapeutic effects of dehydroepiandrosterone metabolites in diabetes mutant mice (C57BL/KsJ-db/db). Endocrinology. 1984 Jul;115(1):239-43. [2]. Kubli-Garfias C, et al. Depressant effect of androgens on the cat brain electrical activity and its antagonism by ruthenium red. Neuroscience. 1982;7(11):2777-82. |
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Chemical & Physical Properties
| Density | 1.085 g/cm3 |
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| Boiling Point | 413.1ºC at 760 mmHg |
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| Melting Point | 154-156ºC |
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| Molecular Formula | C19H30O2 |
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| Molecular Weight | 290.44000 |
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| Flash Point | 176.4ºC |
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| Exact Mass | 290.22500 |
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| PSA | 37.30000 |
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| LogP | 3.95910 |
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| Index of Refraction | 1.536 |
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| InChIKey | QGXBDMJGAMFCBF-XRJZGPCZSA-N |
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| SMILES | CC12CCC3C(CCC4CC(O)CCC43C)C1CCC2=O |
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Synonyms
| Epiaetiocholanolone |
| Epietiocholanolone |
| 3b-hydroxy-5b-androstan-17-one |
| epi-5b-Androsterone |
| b-Etiocholanolone |
| 3b-Etiocholanolone |
| 5b-Epiandrosterone |
