CAS 2657-25-2|2-Benzal-4-hydroxyacetophenone

Introduction：Basic information about CAS 2657-25-2|2-Benzal-4-hydroxyacetophenone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 2-Benzal-4-hydroxyacetophenone BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	2-Benzal-4-hydroxyacetophenone
CAS Number	2657-25-2	Molecular Weight	224.25500
Density	1.191 g/cm3	Boiling Point	419.6ºC at 760 mmHg
Molecular Formula	C₁₅H₁₂O₂	Melting Point	174-178 °C
MSDS	USA	Flash Point	179.1ºC

Names

Name	4'-hydroxychalcone
Synonym	More Synonyms

2-Benzal-4-hydroxyacetophenone BiologicalActivity

Description	4'-Hydroxychalcone, a chalcone isolated from licorice root, with hepatoprotective activity. 4'-Hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. 4'-Hydroxychalcone induces a rapid potassium release from mitochondrial vesicles and causes deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria[1][2][3].
Related Catalog	Research Areas >>OthersSignaling Pathways >>Others >>Others
References	[1]. Inoue B, et al. The effects of echinatin and its related compounds on the mitochondrial energy transfer reaction. J Toxicol Sci. 1982 Nov;7(4):245-54. [2]. Ali Reza, et al. Hepatoprotective activity of phloretin and hydroxychalcones against Acetaminophen Induced hepatotoxicity in mice. Iranian Journal of Pharmaceutical Sciences. 2011 Jan; 7(2). [3]. Orlikova B, et al. The aromatic ketone 4'-hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. Biochem Pharmacol. 2011 Sep 15;82(6):620-31.

Description

4'-Hydroxychalcone, a chalcone isolated from licorice root, with hepatoprotective activity. 4'-Hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. 4'-Hydroxychalcone induces a rapid potassium release from mitochondrial vesicles and causes deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria[1][2][3].

Related Catalog

Research Areas >>OthersSignaling Pathways >>Others >>Others

References

[1]. Inoue B, et al. The effects of echinatin and its related compounds on the mitochondrial energy transfer reaction. J Toxicol Sci. 1982 Nov;7(4):245-54.

[2]. Ali Reza, et al. Hepatoprotective activity of phloretin and hydroxychalcones against Acetaminophen Induced hepatotoxicity in mice. Iranian Journal of Pharmaceutical Sciences. 2011 Jan; 7(2).

[3]. Orlikova B, et al. The aromatic ketone 4'-hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. Biochem Pharmacol. 2011 Sep 15;82(6):620-31.

Chemical & Physical Properties

Density	1.191 g/cm3
Boiling Point	419.6ºC at 760 mmHg
Melting Point	174-178 °C
Molecular Formula	C₁₅H₁₂O₂
Molecular Weight	224.25500
Flash Point	179.1ºC
Exact Mass	224.08400
PSA	37.30000
LogP	3.28830
Vapour Pressure	1.23E-07mmHg at 25°C
Index of Refraction	1.653
InChIKey	UAHGNXFYLAJDIN-IZZDOVSWSA-N
SMILES	O=C(C=Cc1ccccc1)c1ccc(O)cc1

Safety Information

Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S37/39-S26

Synonyms

MFCD00016484

2-BENZAL-4'-HYDROXYACETOPHENONE

BENZYLIDENE-4'-HYDROXYACETOPHENONE

4'-HYDROXYCHALCONE

HYDROXYCHALCONE,4'

4′-Hydroxychalcone

1-(4-Hydroxyphenyl)-3-phenylprop-2-en-1-one

2-Benzylidene-4'-hydroxyacetophenone

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