CAS 54-28-4|(+)-gamma-Tocopherol
| Common Name | (+)-gamma-Tocopherol | ||
|---|---|---|---|
| CAS Number | 54-28-4 | Molecular Weight | 416.68000 |
| Density | 0.933g/cm3 | Boiling Point | 200 °C (0.1 mmHg) |
| Molecular Formula | C28H48O2 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 206ºC |
| Symbol | GHS02, GHS06, GHS08 | Signal Word | Danger |
Names
| Name | γ-tocopherol |
|---|---|
| Synonym | More Synonyms |
(+)-gamma-Tocopherol BiologicalActivity
| Description | γ-Tocopherol (D-γ-Tocopherol) is a potent cyclooxygenase (COX) inhibitor. γ-Tocopherol is a naturally occurring form of Vitamin E in many plant seeds, such as corn oil and soybeans. γ-Tocopherol possesses antiinflammatory properties and anti-cancer activity[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Immunology/Inflammation >>COX |
| Target | Cyclooxygenase |
| In Vitro | γ-Tocopherol (D-γ-Tocopherol) is well absorbed and accumulates to a significant degree in some human tissues; it is metabolized, however, largely to 2,7,8-trimethyl-2-(beta-carboxyethyl)-6-hydroxychroman (gamma-CEHC), which is mainly excreted in the urine[1]. Plasma concentrations of γ-Tocopherol (D-γ-Tocopherol) are inversely associated with the incidence of cardiovascular disease and prostate cancer[1]. |
| References | [1]. Q Jiang, et al. Gamma-Tocopherol, the Major Form of Vitamin E in the US Diet, Deserves More Attention. Am J Clin Nutr. 2001 Dec;74(6):714-22. |
Chemical & Physical Properties
| Density | 0.933g/cm3 |
|---|---|
| Boiling Point | 200 °C (0.1 mmHg) |
| Molecular Formula | C28H48O2 |
| Molecular Weight | 416.68000 |
| Flash Point | 206ºC |
| Exact Mass | 416.36500 |
| PSA | 29.46000 |
| LogP | 8.53180 |
| Index of Refraction | n20/D 1.505 |
| InChIKey | QUEDXNHFTDJVIY-DQCZWYHMSA-N |
| SMILES | Cc1c(O)cc2c(c1C)OC(C)(CCCC(C)CCCC(C)CCCC(C)C)CC2 |
| Storage condition | 2~8°C |
Safety Information
| Symbol | GHS02, GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H301 + H311 + H331-H370 |
| Precautionary Statements | P210-P260-P280-P301 + P310-P311 |
| Personal Protective Equipment | Eyeshields;Gloves |
| Hazard Codes | F |
| Risk Phrases | 11-23/24/25-39/23/24/25 |
| Safety Phrases | S24/25 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 3 |
| HS Code | 2932999099 |
Customs
| HS Code | 2932999099 |
|---|---|
| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles8
More Articles| Fine-scale thermal adaptation in a green turtle nesting population. Proc. Biol. Sci. 279(1731) , 1077-84, (2012) The effect of climate warming on the reproductive success of ectothermic animals is currently a subject of major conservation concern. However, for many threatened species, we still know surprisingly ... | |
| Accumulation of γ- rather than α-tocopherol alters ethylene signaling gene expression in the vte4 mutant of Arabidopsis thaliana. Plant Cell Physiol. 52 , 1389-1400, (2011) Tocopherols are antioxidants found in chloroplasts of leaves, and it is a matter of current debate whether or not they can affect signaling and gene expression in plant cells. For insight into the pos... | |
| Vitamin E isoforms directly bind PKCα and differentially regulate activation of PKCα. Biochem. J. 441(1) , 189-198, (2012) Vitamin E isoforms have opposing regulatory effects on leucocyte recruitment during inflammation. Furthermore, in vitro, vitamin E isoforms have opposing effects on leucocyte migration across endothel... |
Synonyms
| EINECS 200-201-5 |
| D-gamma-Tocopherol |
| MFCD00066529 |
| D-γ-Tocopherol |
| gamma-tocopherol |
