Introduction：Basic information about CAS 2139-47-1|Nifenazone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Nifenazone is a pyrazole drug which can be used in the in the treatment of a variety of rheumatic disorders.
Related Catalog
Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology
References
[1]. HART FD, et al. TRIAL OF NIFENAZONE ("THYLIN"). Br Med J. 1964 Jun 13;1(5397):1553-4.
[2]. Bani-Yaseen AD, et al. The solvatochromic, spectral, and geometrical properties of nifenazone: a DFT/TD-DFT and experimental study. Phys Chem Chem Phys. 2014 Aug 7;16(29):15519-26.
Chemical & Physical Properties
Density
1.33g/cm3
Melting Point
252-253° (also reported as mp 256-258°)
Molecular Formula
C17H16N4O2
Molecular Weight
308.33500
Exact Mass
308.12700
PSA
68.92000
LogP
2.20470
Index of Refraction
1.671
InChIKey
BRZANEXCSZCZCI-UHFFFAOYSA-N
SMILES
Cc1c(NC(=O)c2cccnc2)c(=O)n(-c2ccccc2)n1C
Storage condition
2-8°C
Toxicological Information
CHEMICAL IDENTIFICATION
RTECS NUMBER :
QS4005000
CHEMICAL NAME :
Nicotinamide, N-antipyrinyl-
CAS REGISTRY NUMBER :
2139-47-1
BEILSTEIN REFERENCE NO. :
0307504
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C17-H16-N4-O2
MOLECULAR WEIGHT :
308.37
WISWESSER LINE NOTATION :
T6NJ CVM- DT5NNVJ A1 BR& E1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
7890 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 12,235,1978
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,132,1959
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IJPAAO Indian Journal of Pharmacy. (Bombay, India) V.1-40(1), 1939-78. For publisher information, see IJSIDW. Volume(issue)/page/year: 26,99,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JDGRAX Journal of Drug Research. (National Organization for Drug Research and Control, POB 29, Cairo, Egypt) V.2- 1969- Volume(issue)/page/year: 4,89,1972
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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