Introduction：Basic information about CAS 549-84-8|b-Yohimbine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | b-Yohimbine |
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| CAS Number | 549-84-8 | Molecular Weight | 354.443 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 543.0±50.0 °C at 760 mmHg |
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| Molecular Formula | C21H26N2O3 | Melting Point | / |
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| MSDS | / | Flash Point | 282.2±30.1 °C |
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Names
| Name | .β.-Yohimbine |
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| Synonym | More Synonyms |
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b-Yohimbine BiologicalActivity
| Description | β-Yohimbine (Amsonin) is an indole alkaloid that can be isolated from Aspidosperma ulei Markgr. β-Yohimbine shows antiplasmodial activity against the Chloroquine (HY-17589A)-resistant Fc M29-Cameroon strain (IC50: > 1 μg/mL)[1]. |
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| Related Catalog | Research Areas >>Infection |
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| References | [1]. dos Santos Torres ZE, et al. Chemical composition of Aspidosperma ulei Markgr. and antiplasmodial activity of selected indole alkaloids. Molecules. 2013 May 29;18(6):6281-97. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 543.0±50.0 °C at 760 mmHg |
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| Molecular Formula | C21H26N2O3 |
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| Molecular Weight | 354.443 |
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| Flash Point | 282.2±30.1 °C |
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| Exact Mass | 354.194336 |
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| PSA | 65.56000 |
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| LogP | 2.20 |
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| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
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| Index of Refraction | 1.661 |
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| InChIKey | BLGXFZZNTVWLAY-MQPLHJKPSA-N |
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| SMILES | COC(=O)C1C(O)CCC2CN3CCc4c([nH]c5ccccc45)C3CC21 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- ZG1000030
- CHEMICAL NAME :
- Yohimban-16-alpha-carboxylic acid, 17-beta-hydroxy-, methyl ester
- CAS REGISTRY NUMBER :
- 549-84-8
- LAST UPDATED :
- 199007
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C21-H26-N2-O3
- MOLECULAR WEIGHT :
- 354.49
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948 Volume(issue)/page/year: -,317,1948
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 68 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 94,17,1989
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5400 ug/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 94,17,1989
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Safety Information
Synonyms
| Methyl (16α,17β)-17-hydroxyyohimban-16-carboxylate |
| Yohimban-16α-carboxylic acid, 17β-hydroxy-, methyl ester |
| Yohimban-16-α-carboxylic acid, 17-β-hydroxy-, methyl ester |
| .beta.-Yohimbine |
| Amsonin |
| Yohimban-16α-carboxylic acid, 17β-hydroxy-, methyl ester (8CI) |
| Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (16α,17β)- |
| Amsonine |
| b-Yohimbine |
| β-Yohimbine |
