Introduction：Basic information about CAS 516-55-2|Alloepipregnanolone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Alloepipregnanolone |
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| CAS Number | 516-55-2 | Molecular Weight | 318.49300 |
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| Density | 1.053g/cm3 | Boiling Point | 431.2ºC at 760mmHg |
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| Molecular Formula | C21H34O2 | Melting Point | 200℃ |
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| MSDS | / | Flash Point | 183.9ºC |
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Names
| Name | 3β-hydroxy-5α-pregnan-20-one |
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| Synonym | More Synonyms |
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Alloepipregnanolone BiologicalActivity
| Description | Alloepipregnanolone, a pregnane with anesthetic, hypnotic, and sedative properties, interferes with the development of rapid tolerance to the anxiolytic effect of ethanol. |
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| Related Catalog | Research Areas >>Metabolic DiseaseNatural Products >>Others |
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| Target | Human Endogenous Metabolite |
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| In Vivo | On day 2, pretreatment with a 0.20 mg/kg dose of Alloepipregnanolone blocks the development of rapid tolerance to the anxiolytic effect of ethanol. However, there is a significant decrease in the anxiolytic effect in the control groups that received ethanol on both days (EE), suggesting that the 1.5 g/kg dose of ethanol results in rapid tolerance. The post hoc analysis confirms that the 0.20 mg/kg pretreatment with Alloepipregnanolone blocks the rapid tolerance compared to the control groups, although the 0.10 mg/kg dose only partially blocks the development of such tolerance. However, the 0.05 mg/kg dose has no effect on the development of rapid tolerance to ethanol[1]. |
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| Animal Admin | Mice[1] Male Swiss mice are pretreated with Alloepipregnanolone (isopregnanolone: 0.05, 0.10 or 0.20 mg/kg) 30 min before administration of ethanol (1.5 g/kg). Twenty-four hours later, all animals tested using the plus-maze apparatus. The first experiment defines the doses of ethanol that does or does not induce rapid tolerance to the anxiolytic effect of ethanol. In the second, the influence of pretreatment of mice with Alloepipregnanolone (0.05, 0.10 or 0.20 mg/kg) on rapid tolerance to ethanol (1.5 g/kg) is studied[1]. |
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| References | [1]. Debatin T, et al. Effect of isopregnanolone on rapid tolerance to the anxiolytic effect of ethanol. Rev Bras Psiquiatr. 2006 Mar;28(1):18-23. |
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Chemical & Physical Properties
| Density | 1.053g/cm3 |
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| Boiling Point | 431.2ºC at 760mmHg |
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| Melting Point | 200℃ |
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| Molecular Formula | C21H34O2 |
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| Molecular Weight | 318.49300 |
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| Flash Point | 183.9ºC |
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| Exact Mass | 318.25600 |
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| PSA | 37.30000 |
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| LogP | 4.59520 |
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| Index of Refraction | 1.524 |
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| InChIKey | AURFZBICLPNKBZ-FZCSVUEKSA-N |
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| SMILES | CC(=O)C1CCC2C3CCC4CC(O)CCC4(C)C3CCC12C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- TU4383200
- CHEMICAL NAME :
- 5-alpha-Pregnan-20-one, 3-beta-hydroxy-
- CAS REGISTRY NUMBER :
- 516-55-2
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C21-H34-O2
- MOLECULAR WEIGHT :
- 318.55
- WISWESSER LINE NOTATION :
- L E5 B666TJ A1 E1 FV1 OQ
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 40 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 11,117,1968
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Safety Information
Synonyms
| ALLOPREGNAN-3B-OL-20-ONE |
| 3beta-hydroxy-5alpha-pregnan-20-one |
| 3-Hydroxypregnan-20-one |
| Alloepipregnanolone |
| 5A-PREGNAN-3B-OL-20-ONE |
| Tetrahydroprogesterone |
| ALLOPREGNANOLONE |
| ISOPREGNANOLONE |
| EINECS 208-224-2 |
| MFCD00064935 |
| Pregnan-20-one,3-hydroxy-, (3b,5a)- |
| epi-allopregnanolone |
