Introduction：Basic information about CAS 5784-74-7|Salsolidine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Salsolidine |
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| CAS Number | 5784-74-7 | Molecular Weight | 207.26900 |
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| Density | 1.034g/cm3 | Boiling Point | 313.4ºC at 760 mmHg |
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| Molecular Formula | C12H17NO2 | Melting Point | / |
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| MSDS | / | Flash Point | 127.1ºC |
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Names
| Name | 6,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydro-isoquinoline |
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| Synonym | More Synonyms |
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Salsolidine BiologicalActivity
| Description | Salsolidine is a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A inhibitor. |
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| Related Catalog | Signaling Pathways >>Neuronal Signaling >>Monoamine OxidaseNatural Products >>AlkaloidResearch Areas >>Neurological Disease |
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| Target | MAO A[1] |
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| In Vitro | Salsolidine is a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A inhibitor. The R-salsolidine is more active against MAO A than S-salsolidine (Ki, 6 μM and 186 μM)[1]. Salsolidine weakly inhibits the binding of δ-receptor, with a Ki of >100 μM[2]. Salsolidine has the potential of inhibiting Acetylcholinestearse and butyrylcholinesterase[3]. |
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| References | [1]. Bembenek ME, et al. Inhibition of monoamine oxidases A and B by simple isoquinoline alkaloids: racemic and optically active 1,2,3,4-tetrahydro-, 3,4-dihydro-, and fully aromatic isoquinolines. J Med Chem. 1990 Jan;33(1):147-52. [2]. Airaksinen MM, et al. Binding of beta-carbolines and tetrahydroisoquinolines by opiate receptors of the delta-type. Acta Pharmacol Toxicol (Copenh). 1984 Nov;55(5):380-5. [3]. Tundis R, et al. A potential role of alkaloid extracts from Salsola species (Chenopodiaceae) in the treatment of Alzheimer's disease. J Enzyme Inhib Med Chem. 2009 Jun;24(3):818-24. |
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Chemical & Physical Properties
| Density | 1.034g/cm3 |
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| Boiling Point | 313.4ºC at 760 mmHg |
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| Molecular Formula | C12H17NO2 |
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| Molecular Weight | 207.26900 |
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| Flash Point | 127.1ºC |
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| Exact Mass | 207.12600 |
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| PSA | 30.49000 |
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| LogP | 2.23930 |
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| InChIKey | HMYJLVDKPJHJCF-UHFFFAOYSA-N |
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| SMILES | COc1cc2c(cc1OC)C(C)NCC2 |
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| Storage condition | 2-8℃ |
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Safety Information
| Hazard Codes | Xi |
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| HS Code | 2933499090 |
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Customs
| HS Code | 2933499090 |
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| Summary | 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| rac-salsolidine |
| 6,7-DIMETHOXY-1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE |
| 1,2,3,4-tetrahydro-6,7-dimethoxy-1-methylisoquinoline |
| 1-methyl-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline |
| Salsolidine |
