CAS 1148-11-4|Z-Pro-OH

Introduction：Basic information about CAS 1148-11-4|Z-Pro-OH, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Z-Pro-OH BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles5
8. Synonyms

Common Name	Z-Pro-OH
CAS Number	1148-11-4	Molecular Weight	249.262
Density	1.3±0.1 g/cm3	Boiling Point	432.3±45.0 °C at 760 mmHg
Molecular Formula	C₁₃H₁₅NO₄	Melting Point	76-78ºC
MSDS	ChineseUSA	Flash Point	215.3±28.7 °C

Names

Name	(2S)-1-phenylmethoxycarbonylpyrrolidine-2-carboxylic acid
Synonym	More Synonyms

Z-Pro-OH BiologicalActivity

Description	Carbobenzoxyproline (L-Cbz-Proline) is an inhibitor of prolidase. Carbobenzoxyproline can be used for prolidase deficiency (PD) research[1].
Related Catalog	Research Areas >>OthersSignaling Pathways >>Others >>Others
In Vitro	Carbobenzoxyproline (6 mM; 0-10 d; pH=6.0) causes mitochondrial depolarization and increases cellular death by 33% as reported for long-term culture of fibroblasts from prolidase deficiency (PD) patients[1]. Carbobenzoxyproline (0, 1, 3, 6 mM; 1 min; pH=6.0) results fibroblasts prolidase (FBP) hydrolysis, shows linear competitive inhibition[1].
In Vivo	Carbobenzoxyproline (60 mg/kg; injection; once daily; 3 weeks) serves as in vivo inhibitor of erythrocytes prolidase in mice model[1]. Animal Model: C57Bl/6J mice (4-week-old)[1] Dosage: 60 mg/kg Administration: Injection; once daily for 3 weeks Result: Resulted significant reduction of erythrocytes prolidase activity.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	432.3±45.0 °C at 760 mmHg
Melting Point	76-78ºC
Molecular Formula	C₁₃H₁₅NO₄
Molecular Weight	249.262
Flash Point	215.3±28.7 °C
Exact Mass	249.100113
PSA	66.84000
LogP	1.17
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.582
InChIKey	JXGVXCZADZNAMJ-NSHDSACASA-N
SMILES	O=C(O)C1CCCN1C(=O)OCc1ccccc1
Storage condition	2~8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UY0745000

CHEMICAL NAME :: 1,2-Pyrrolidinedicarboxylic acid, 1-benzyl ester, L-

CAS REGISTRY NUMBER :: 1148-11-4

LAST UPDATED :: 199406

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C13-H15-N-O4

MOLECULAR WEIGHT :: 249.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravaginal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 68,696,1979 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 280 mg/kg

SEX/DURATION :: female 28 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 68,696,1979

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravaginal

DOSE :: 280 ug/kg

SEX/DURATION :: female 28 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 68,696,1979

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn
Risk Phrases	R62
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	UY0745000
HS Code	2933990090

Customs

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles5

Prolidase is required for early trafficking events during influenza A virus entry.

J. Virol. 88(19) , 11271-83, (2014)

Influenza A virus (IAV) entry is a multistep process that requires the interaction of the virus with numerous host factors. In this study, we demonstrate that prolidase (PEPD) is a cellular factor req...

N-benzyloxycarbonyl-L-proline: an in vitro and in vivo inhibitor of prolidase.

Biochim. Biophys. Acta 1744(2) , 157-63, (2005)

Prolidase deficiency (PD) is a recessive disorder of the connective tissue caused by mutations in the prolidase, a specific peptidase, cleaving the dipeptides with a C-terminal prolyl and hydroxyproly...

Proline prodrug of melphalan targeted to prolidase, a prodrug activating enzyme overexpressed in melanoma.

Pharm. Res. 24(7) , 1290-8, (2007)

To determine the bioactivation and uptake of prolidase-targeted proline prodrugs of melphalan in six cancer cell lines with variable prolidase expression and to evaluate prolidase-dependence of prodru...

Synonyms

(S)-N-(benzyloxycarbonyl)-proline

Cbz-L-proline

1,2-Pyrrolidinedicarboxylic acid, 1-benzyl ester, L-

EINECS 214-557-4

(S)-1-(benzyloxycarbonyl)-pyrrolidine-2-carboxylic acid

(S)-N-CBZ-pyrrolidine-2-carboxylic acid

N-Benzyloxycarbonyl-L-proline

N-Carbobenzyloxy-L-proline

(2S)-1-[(Phenylmethoxy)carbonyl]pyrrolidine-2-carboxylic acid

Carbobenzyloxy-L-proline

MFCD00003170

1,2-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl) ester, (2S)-

N-Carbobenzoxy-L-proline

(S)-1-carbobenzoxypyrrolidine-2-carboxylic acid

MFCD00020830

1,2-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl) ester, (S)-

Carbobenzoxy-L-proline

1-[(Benzyloxy)carbonyl]-L-proline

N-Cbz-L-proline

N-benzyloxycarbonyl-(S)-proline

(2S)-1-Phenylmethoxycarbonylpyrrolidine-2-carboxylicacid

Z-L-Proline

1,2-Pyrrolidinedicarboxylic acid, 1-(phenylmethyl) ester, (S)- (9CI)

Z-Pro-OH

N-[(phenyl-methoxy)carbonyl]-L-proline

Benzyloxycarbonyl-L-proline

Recommended......