Introduction：Basic information about CAS 20150-34-9|Ferrous bisglycinate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ferrous bisglycinate |
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| CAS Number | 20150-34-9 | Molecular Weight | 203.962 |
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| Density | / | Boiling Point | 240.9ºC at 760 mmHg |
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| Molecular Formula | C4H8FeN2O4 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Ferrous Bisglycinate Food Grade |
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| Synonym | More Synonyms |
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Ferrous bisglycinate BiologicalActivity
| Description | Ferrous bisglycinate is an orally active iron fortificants and therapeutic iron supplements. Ferrous bisglycinate can be used for the research of iron deficiency anemia[1][2]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/ImmunologyResearch Areas >>Metabolic Disease |
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| In Vitro | Ferrous bisglycinate (25-200 μM; 2 h) does not affect the Caco-2 cells viability[2]. Ferrous bisglycinate (25 μM; 2 h) increases ferritin content in the Caco-2 cells[2]. Cell Viability Assay[2] Cell Line: Caco-2 cells Concentration: 0, 25, 50, 100, 200 μM Incubation Time: 2 hours Result: Did not affect the viability of wild-type and divalent metal transporter 1 (DMT1) knockout Caco-2 cells. Western Blot Analysis[2] Cell Line: Caco-2 cells Concentration: 25 μM Incubation Time: 2 hours Result: Increased ferritin content and decreased DMT1 expression levels significantly in the wild-type cells. |
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| In Vivo | Ferrous bisglycinate (500 mg/kg iron; p.o.) exerts a protective effect on colitis in mice[3]. Animal Model: Female C57BL/6 mice are induced colitis by dextran sodium sulfate (DSS)[3] Dosage: 500 mg/kg iron Administration: P.o. (add to the diet) for 10 days Result: Had the best survival rates (100%). Caused the least body lost (9% body loss). |
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| References | [1]. Ferrari P, et, al. Treatment of mild non-chemotherapy-induced iron deficiency anemia in cancer patients: comparison between oral ferrous bisglycinate chelate and ferrous sulfate. Biomed Pharmacother. 2012 Sep; 66(6): 414-8. [2]. Yu X, et, al. Iron Transport from Ferrous Bisglycinate and Ferrous Sulfate in DMT1-Knockout Human Intestinal Caco-2 Cells. Nutrients. 2019 Feb 26; 11(3): 485. [3]. Constante M, et, al. Iron Supplements Modulate Colon Microbiota Composition and Potentiate the Protective Effects of Probiotics in Dextran Sodium Sulfate-induced Colitis. Inflamm Bowel Dis. 2017 May; 23(5): 753-766. |
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Chemical & Physical Properties
| Boiling Point | 240.9ºC at 760 mmHg |
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| Molecular Formula | C4H8FeN2O4 |
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| Molecular Weight | 203.962 |
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| Exact Mass | 203.983353 |
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| PSA | 132.30000 |
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| InChIKey | GIPOFCXYHMWROH-UHFFFAOYSA-L |
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| SMILES | NCC(=O)[O-].NCC(=O)[O-].[Fe+2] |
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Safety Information
Synonyms
| Iron protochloride |
| Natural lawrencite |
| Ferro 66 |
| ferrous bisglycinate |
| ferrous glycinate |
| FERROUS CHLORIDE |
| FeCl2 |
| iron dichloride |
| ferrous dichloride |
