CAS 206265-98-7|Boc-NH-PEG7-NH2

Introduction:Basic information about CAS 206265-98-7|Boc-NH-PEG7-NH2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameBoc-NH-PEG7-NH2
CAS Number206265-98-7Molecular Weight468.58200
Density1.075g/cm3Boiling Point547.7ºC at 760 mmHg
Molecular FormulaC21H44N2O9Melting Point/
MSDSUSAFlash Point285ºC

Names

Nametert-butyl N-[2-[2-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]carbamate
SynonymMore Synonyms

Boc-NH-PEG7-NH2 BiologicalActivity

DescriptionBoc-NH-PEG7-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related CatalogResearch Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker
Target

PEGs

Alkyl/ether

In VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

Density1.075g/cm3
Boiling Point547.7ºC at 760 mmHg
Molecular FormulaC21H44N2O9
Molecular Weight468.58200
Flash Point285ºC
Exact Mass468.30500
PSA128.96000
LogP1.67720
Vapour Pressure4.75E-12mmHg at 25°C
Index of Refraction1.464
InChIKeyHTIMIYPOESODPC-UHFFFAOYSA-N
SMILESCC(C)(C)OC(=O)NCCOCCOCCOCCOCCOCCOCCOCCN

Safety Information

Personal Protective EquipmentEyeshields;Gloves
RIDADRNONH for all modes of transport
WGK Germany3

Synonyms

Boc-NH-PEG7-CH2CH2NH2
25-Amino-5,8,11,14,17,20,23-heptaoxa-2-azapentacosanoic Acid1,1-Dimethylethyl Ester
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