CAS 207121-48-0|L-Cysteinesulfinic acid monohydrate
Introduction：Basic information about CAS 207121-48-0|L-Cysteinesulfinic acid monohydrate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | L-Cysteinesulfinic acid monohydrate | ||
|---|---|---|---|
| CAS Number | 207121-48-0 | Molecular Weight | 171.17200 |
| Density | / | Boiling Point | 580.6ºC at 760 mmHg |
| Molecular Formula | C3H9NO5S | Melting Point | 163ºC (dec.)(lit.) |
| MSDS | ChineseUSA | Flash Point | 304.9ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | L-Cysteinesulfinic Acid, Monohydrate |
|---|---|
| Synonym | More Synonyms |
L-Cysteinesulfinic acid monohydrate BiologicalActivity
| Description | L-Cysteinesulfinic acid monohydrate is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>mGluRResearch Areas >>Neurological Disease |
| Target | mGluR1:3.92 (pEC50) mGluR2:3.9 (pEC50) mGluR4:2.7 (pEC50) mGluR5:4.6 (pEC50) mGluR6:4.0 (pEC50) mGluR8:3.94 (pEC50) |
| In Vitro | L-Cysteinesulfinic acid is an endogenous agonist of a metabotropic receptor coupled to stimulation of phospholipase D (PLD) activity. L-CSA is an endogenous agonist of the PLD-coupled metabotropic excitatory amino acids (EAA) receptor. L-CSA selectively activates the PLD-coupled receptor. 1 mM L-CSA induces a significant increase in PLD activity in hippocampal slices, whereas 1 mM concentrations of L-glutamate, L-aspartate, and L-HCA are without effect. L-CSA elicits a dose-dependent increase in PLD activity in rat hippocampal slices in the presence of iGluR antagonists, with an approximate EC50 of 500 uM. The PLD response induced by 1 mM L-CSA is not significantly decreased in the presence of 1 uM tetrodotoxin, suggesting that this response is not dependent upon L-CSA-induced increases in cell firing[1]. |
| References | [1]. Shi Q, et al. L-homocysteine sulfinic acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonists. J Pharmacol Exp Ther. 2003 Apr;305(1):131-42. [2]. Boss V, et al. L-cysteine sulfinic acid as an endogenous agonist of a novel metabotropic receptor coupled to stimulation of phospholipase D activity. |
Chemical & Physical Properties
| Boiling Point | 580.6ºC at 760 mmHg |
|---|---|
| Melting Point | 163ºC (dec.)(lit.) |
| Molecular Formula | C3H9NO5S |
| Molecular Weight | 171.17200 |
| Flash Point | 304.9ºC |
| Exact Mass | 171.02000 |
| PSA | 129.06000 |
| LogP | 0.12170 |
| Vapour Pressure | 2.73E-15mmHg at 25°C |
| InChIKey | YQIXTMZYGQXTCZ-DKWTVANSSA-N |
| SMILES | NC(CS(=O)O)C(=O)O.O |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi |
| Risk Phrases | 36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2930909090 |
Customs
| HS Code | 2930909090 |
|---|---|
| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Articles1
More Articles| Cysteine sulphinate (CSA) as an excitatory amino acid transmitter candidate in the mammalian central nervous system. Prog. Neurobiol. 35 , 313, (1990) |
Synonyms
| MFCD00150732 |
| EINECS 214-228-5 |
| L-cysteinesulfinic acid monohydrate |
