CAS 261766-32-9|N-(2-Phenylethyl)indomethacin Amide
Introduction：Basic information about CAS 261766-32-9|N-(2-Phenylethyl)indomethacin Amide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | N-(2-Phenylethyl)indomethacin Amide | ||
|---|---|---|---|
| CAS Number | 261766-32-9 | Molecular Weight | 460.95 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 640.5±55.0 °C at 760 mmHg |
| Molecular Formula | C27H25ClN2O3 | Melting Point | / |
| MSDS | / | Flash Point | 341.2±31.5 °C |
Names
| Name | N-(2-Phenylethyl)indomethacin Amide |
|---|---|
| Synonym | More Synonyms |
N-(2-Phenylethyl)indomethacin Amide BiologicalActivity
| Description | LM-4108 (N-(2-Phenylethyl)-indomethacin amide) is a selective and orally active COX-2 inhibitor with an IC50 of 0.06 μM for purified human COX-2. LM-4108 shows anti-inflammatory activity and may be effective in prevention of cancer. Half-lives for the disappearance of 10 μM LM-4108 in rat, human, and mouse liver microsomes were 11 min, 21 min, and 51 min, respectively[1]. |
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| Related Catalog | Research Areas >>CancerResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Immunology/Inflammation >>COX |
| Target | Human COX-2:60 nM (IC50) Ovine COX-1:>66 μM (IC50) |
| References | [1]. Rory P Remmel, et al. Studies on the metabolism of the novel, selective cyclooxygenase-2 inhibitor indomethacin phenethylamide in rat, mouse, and human liver microsomes: identification of active metabolites. Drug Metab Dispos. 2004 Jan;32(1):113-22. [2]. Remmel R P, et al. Studies on the metabolism of the novel, selective cyclooxygenase-2 inhibitor indomethacin phenethylamide in rat, mouse, and human liver microsomes: identification of active metabolites. Drug metabolism and disposition, 2004, 32(1): 113-122. |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 640.5±55.0 °C at 760 mmHg |
| Molecular Formula | C27H25ClN2O3 |
| Molecular Weight | 460.95 |
| Flash Point | 341.2±31.5 °C |
| Exact Mass | 460.155365 |
| PSA | 63.82000 |
| LogP | 4.31 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.613 |
| InChIKey | VYDBTNADENXYSN-UHFFFAOYSA-N |
| SMILES | COc1ccc2c(c1)c(CC(=O)NCCc1ccccc1)c(C)n2C(=O)c1ccc(Cl)cc1 |
Synonyms
| 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-N-(2-phenylethyl)acetamide |
| 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-N-(2-phenylethyl)acetamide |
| 1H-Indole-3-acetamide, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-N-(2-phenylethyl)- |
