CAS 9004-57-3|Ethyl cellulose
Introduction：Basic information about CAS 9004-57-3|Ethyl cellulose, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ethyl cellulose | ||
|---|---|---|---|
| CAS Number | 9004-57-3 | Molecular Weight | 448.474 |
| Density | 1.45 | Boiling Point | 654.2±55.0 °C at 760 mmHg |
| Molecular Formula | C23H24N6O4 | Melting Point | 240-255ºC |
| MSDS | ChineseUSA | Flash Point | 349.5±31.5 °C |
Names
| Name | Ethyl cellulose |
|---|---|
| Synonym | More Synonyms |
Ethyl cellulose BiologicalActivity
| Description | Ethyl cellulose is a derivative of cellulose. Ethyl cellulose serves as a non-toxic and biodegradable polymer, with unique properties such as oleogel formation, delivery of active component, and film-forming ability in the food and pharmaceutical sectors. Ethyl cellulose can be used as an excipient, such as coating agent, flavoring agent, tablet filler. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| References | [1]. Ahmadi P, Jahanban-Esfahlan A, Ahmadi A, et al. Development of ethyl cellulose-based formulations: A perspective on the novel technical methods[J]. Food Reviews International, 2022, 38(4): 685-732. [2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99. |
Chemical & Physical Properties
| Density | 1.45 |
|---|---|
| Boiling Point | 654.2±55.0 °C at 760 mmHg |
| Melting Point | 240-255ºC |
| Molecular Formula | C23H24N6O4 |
| Molecular Weight | 448.474 |
| Flash Point | 349.5±31.5 °C |
| Exact Mass | 448.185913 |
| PSA | 147.66000 |
| LogP | 6.62 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.14 |
| InChIKey | ZZSNKZQZMQGXPY-UHFFFAOYSA-N |
| SMILES | CCOCC1OC(OC)C(OCC)C(OCC)C1OC1OC(CO)C(OC)C(O)C1O |
| Storage condition | room temp |
| Water Solubility | insoluble |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 19,97,1981 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 19,113,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 19,113,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82229 No. of Facilities: 10802 (estimated) No. of Industries: 130 No. of Occupations: 90 No. of Employees: 98834 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5864 No. of Facilities: 6051 (estimated) No. of Industries: 79 No. of Occupations: 80 No. of Employees: 74759 (estimated) No. of Female Employees: 27837 (estimated)
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi:Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 1 |
| RTECS | FJ5950500 |
Articles40
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| Effects of molecular weight on permeability and microstructure of mixed ethyl-hydroxypropyl-cellulose films. Eur. J. Pharm. Sci. 48(1-2) , 240-8, (2013) Films of ethyl cellulose (EC) and water-soluble hydroxypropyl cellulose (HPC) can be used for extended release coatings in oral formulations. The permeability and microstructure of free EC/HPC films w... | |
| Mucosa-plate for direct evaluation of mucoadhesion of drug carriers. Int. J. Pharm. 441(1-2) , 801-8, (2013) The method to prepare mucosa-plates, glass slides covalently coated with mucin, is demonstrated. The use of the plate to evaluate mucoadhesion of nanocarriers made from different four polymeric materi... |
Synonyms
| 1,3-Benzenedicarbonitrile, 2-((4-((2-(acetyloxy)ethyl)butylamino)-2-methylphenyl)azo)-5-nitro- |
| EINECS 232-674-9 |
| 2-(Butyl{4-[(E)-(2,6-dicyano-4-nitrophenyl)diazenyl]-3-methylphenyl}amino)ethyl acetate |
| 2-(Butyl{4-[(E)-(2,6-dicyano-4-nitrophenyl)diazenyl]-3-methylphen yl}amino)ethyl acetate |
| 1,3-Benzenedicarbonitrile, 2-[(E)-2-[4-[[2-(acetyloxy)ethyl]butylamino]-2-methylphenyl]diazenyl]-5-nitro- |
| MFCD00131037 |
| n-butyl-n-(2-acetoxyethyl)-4-((4-nitro-2,6-dicyanophenyl)azo)-3-methylbenzeneamine |
