Introduction：Basic information about CAS 1165910-22-4|LGD-4033, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | LGD-4033 |
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| CAS Number | 1165910-22-4 | Molecular Weight | 338.248 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 439.9±45.0 °C at 760 mmHg |
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| Molecular Formula | C14H12F6N2O | Melting Point | / |
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| MSDS | / | Flash Point | 219.8±28.7 °C |
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Names
| Name | 4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile |
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| Synonym | More Synonyms |
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LGD-4033 BiologicalActivity
| Description | LGD-4033 is a novel nonsteroidal, oral SARM that binds to androgen receptor with high affinity (Ki of 1 nM) and selectivity.IC50 value: 1 nM (Ki, for androgen receptor) Target: androgen receptorin vitro: LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, binds androgen receptor with high affinity and selectivity.in vivo: LGD-4033 has demonstrated anabolic activity in the muscle, anti-resorptive and anabolic activity in bone, and robust selectivity for muscle versus prostate In animal models. LGD-4033 is well tolerated, has a long elimination half-life and dose-proportional accumulation upon multiple dosing. LGD-4033 is safe, has favorable pharmacokinetic profile, and increases lean body mass even during this short period without change in prostate-specific antigen. |
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| Related Catalog | Signaling Pathways >>Others >>Androgen ReceptorResearch Areas >>Endocrinology |
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| References | [1]. Basaria S,et al. The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men. J Gerontol A Biol Sci Med Sci. 2013 Jan;68(1):87-95. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 439.9±45.0 °C at 760 mmHg |
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| Molecular Formula | C14H12F6N2O |
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| Molecular Weight | 338.248 |
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| Flash Point | 219.8±28.7 °C |
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| Exact Mass | 338.085388 |
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| PSA | 47.26000 |
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| LogP | 4.04 |
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| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
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| Index of Refraction | 1.496 |
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| InChIKey | OPSIVAKKLQRWKC-VXGBXAGGSA-N |
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| SMILES | N#Cc1ccc(N2CCCC2C(O)C(F)(F)F)cc1C(F)(F)F |
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| Storage condition | -20℃ |
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Safety Information
Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 4-{(2R)-2-[(1R)-2,2,2-Trifluoro-1-hydroxyethyl]-1-pyrrolidinyl}-2-(trifluoromethyl)benzonitrile |
| Benzonitrile, 4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]-1-pyrrolidinyl]-2-(trifluoromethyl)- |
| LGD-4033 |
| Lingandro |
| LGD4033 |
