Introduction：Basic information about CAS 145739-56-6|Tetomilast, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tetomilast |
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| CAS Number | 145739-56-6 | Molecular Weight | 369.434 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 526.1±50.0 °C at 760 mmHg |
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| Molecular Formula | C19H18N2O4S | Melting Point | / |
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| MSDS | / | Flash Point | 272.0±30.1 °C |
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Names
| Name | 6-[2-(3,4-diethoxyphenyl)-1,3-thiazol-4-yl]pyridine-2-carboxylic acid |
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| Synonym | More Synonyms |
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Tetomilast BiologicalActivity
| Description | Tetomilast (OPC-6535) is a PDE4 inhibitor with potential for the treatment of inflammatory bowel disease (IBD) and chronic obstructive pulmonary disease (COPD). |
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| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Phosphodiesterase (PDE)Research Areas >>Inflammation/Immunology |
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| References | [1]. Ichikawa H, Okamoto S, Kamada N, et al. Tetomilast suppressed production of proinflammatory cytokines from human monocytes and ameliorated chronic colitis in IL-10-deficient mice. Inflamm Bowel Dis. 2008;14(11):1483-1490. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 526.1±50.0 °C at 760 mmHg |
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| Molecular Formula | C19H18N2O4S |
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| Molecular Weight | 369.434 |
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| Flash Point | 272.0±30.1 °C |
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| Exact Mass | 369.103485 |
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| PSA | 109.78000 |
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| LogP | 4.39 |
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| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
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| Index of Refraction | 1.601 |
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| InChIKey | XDBHURGONHZNJF-UHFFFAOYSA-N |
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| SMILES | CCOc1ccc(-c2nc(-c3cccc(C(=O)O)n3)cs2)cc1OCC |
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Safety Information
Customs
| HS Code | 2934100090 |
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| Summary | 2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |
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Synonyms
| Tetomilast |
| 2-Pyridinecarboxylic acid, 6-[5-(3,4-diethoxyphenyl)-3-thienyl]- |
| UNII-S6RXB5KF56 |
| 6-[5-(3,4-Diethoxyphenyl)-3-thienyl]-2-pyridinecarboxylic acid |
| 6-[2-(3,4-diethoxypheny)-1,3-thiazol-4-yl]pyridine-2-carboxylic acid |
