CAS 21442-01-3|N-(2-HYDROXYPROPYL)METHACRYLAMIDE
| Common Name | N-(2-HYDROXYPROPYL)METHACRYLAMIDE | ||
|---|---|---|---|
| CAS Number | 21442-01-3 | Molecular Weight | 143.18400 |
| Density | 1.002g/cm3 | Boiling Point | 321.2ºC at 760mmHg |
| Molecular Formula | C7H13NO2 | Melting Point | 70 °C |
| MSDS | ChineseUSA | Flash Point | 148.1ºC |
Names
| Name | n-(2-hydroxypropyl)methacrylamide |
|---|---|
| Synonym | More Synonyms |
N-(2-HYDROXYPROPYL)METHACRYLAMIDE BiologicalActivity
| Description | N-(2-Hydroxypropyl)methacrylamide is used to synthesize copolymers for the targeted delivery of antileishmanial agents in Visceral leishmaniasis (VL) [1][1]. |
|---|---|
| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Others >>Others |
| In Vivo | At 5 mg/kg body weight drug equivalent dose, all N-(2-Hydroxypropyl)methacrylamide copolymer-drug conjugates which contained lysosomally degradable side chains shows significant in vivo antileishmanial activity (>99% inhibition)[1]. |
| References | [1]. Nan A, et al. N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers for targeted delivery of 8-aminoquinoline antileishmanial drugs. J Control Release. 2001 Dec 13;77(3):233-43. [2]. Hao Tang, et al. Comb-like Poly(N-(2-hydroxypropyl) methacrylamide) Doxorubicin Conjugates: The Influence of Polymer Architecture and Composition on the Biological Properties. Chinese Journal of Polymer Science volume 36, pages1225-1238(2018). |
Chemical & Physical Properties
| Density | 1.002g/cm3 |
|---|---|
| Boiling Point | 321.2ºC at 760mmHg |
| Melting Point | 70 °C |
| Molecular Formula | C7H13NO2 |
| Molecular Weight | 143.18400 |
| Flash Point | 148.1ºC |
| Exact Mass | 143.09500 |
| PSA | 49.33000 |
| LogP | 0.45040 |
| Vapour Pressure | 2.43E-05mmHg at 25°C |
| Index of Refraction | 1.46 |
Safety Information
| Risk Phrases | 36/37/38 |
|---|---|
| Safety Phrases | 26-36/37/39 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2924199090 |
Customs
| HS Code | 2924199090 |
|---|---|
| Summary | 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Articles4
More Articles| The influence of linker length on the properties of cathepsin S cleavable177Lu-labeled HPMA copolymers for pancreatic cancer imaging Biomaterials 35(22) , 5760-70, (2014) N-(2-hydroxypropyl)-methacrylamide (HPMA) copolymers have shown promise for application in the detection and staging of cancer. However, non-target accumulation, particularly in the liver and spleen, ... | |
| Enhanced transcellular penetration and drug delivery by crosslinked polymeric micelles into pancreatic multicellular tumor spheroids. Biomater. Sci. 3 , 1085-95, (2015) Many attempts have been made in the application of multicellular tumor spheroids (MCTS) as a 3D tumor model to investigate their biological responses upon introduction of polymeric micelles as nanocar... | |
| Vesicular glutamate transporter expression level affects synaptic vesicle release probability at hippocampal synapses in culture. J. Neurosci. 34(35) , 11781-91, (2014) The vesicular glutamate transporter (VGLUT) plays an essential role in synaptic transmission by filling vesicles with glutamate. At mammalian synapses, VGLUT expression level determines the amount of ... |
Synonyms
| 1-methacryloylamino-2-hydroxypropane |
