Introduction：Basic information about CAS 354811-10-2|(5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (5-PHENYL-2-UREIDO)THIOPHENE-3-CARBOXAMIDE |
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| CAS Number | 354811-10-2 | Molecular Weight | 261.30 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C12H11N3O2S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 2-(carbamoylamino)-5-phenylthiophene-3-carboxamide |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | IKK2-IN-4 (compound 4) is a potent IKK-2 inhibitor, with an IC50 of 25 nM. IKK2-IN-4 can inhibit the LPS-induced production of TNFα in PBMCs[1]. |
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| Related Catalog | Signaling Pathways >>NF-κB >>IKKResearch Areas >>Inflammation/Immunology |
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| Target | IKK-2:25 nM (IC50) |
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| References | [1]. Baxter A, et, al. Hit-to-lead studies: the discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2817-22. |
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Chemical & Physical Properties
| Molecular Formula | C12H11N3O2S |
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| Molecular Weight | 261.30 |
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| Exact Mass | 261.05700 |
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| PSA | 128.43000 |
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| LogP | 3.47560 |
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| InChIKey | PSVUSJKZJQMCSP-UHFFFAOYSA-N |
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| SMILES | NC(=O)Nc1sc(-c2ccccc2)cc1C(N)=O |
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Synonyms
| IN1462 |
| HMS3229F13 |
| HMS2043P17 |
| IKK-2 Inhibitor VI |
