Introduction：Basic information about CAS 99624-27-8|Kazinol B, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Kazinol B |
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| CAS Number | 99624-27-8 | Molecular Weight | 392.487 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 556.6±50.0 °C at 760 mmHg |
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| Molecular Formula | C25H28O4 | Melting Point | / |
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| MSDS | / | Flash Point | 290.4±30.1 °C |
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Names
| Name | Kazinol B |
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| Synonym | More Synonyms |
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Kazinol B BiologicalActivity
| Description | Kazinol B, a prenylated flavan with a dimethyl pyrane ring, is an inhibitor of nitric oxide (NO) production. Kazinol B improves insulin sensitivity by enhancing glucose uptake via the insulin-Akt signaling pathway and AMPK activation. Kazinol B has the potential for diabetes mellitus research[1][2]. |
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| Related Catalog | Signaling Pathways >>Epigenetics >>AMPKSignaling Pathways >>Immunology/Inflammation >>NO SynthaseSignaling Pathways >>PI3K/Akt/mTOR >>AktSignaling Pathways >>PI3K/Akt/mTOR >>AMPKResearch Areas >>Metabolic Disease |
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| Target | Akt AMPK |
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| In Vitro | Kazinol B (2, 10 and 20 μM; 72 hours) shows no toxicity to adipocytes in 3T3-L1 cells[1]. Kazinol B (2-20 μM; 72 hours) dose-dependently increases lipid accumulation by 2.4-fold (at 20 μM) treatment as compared with MDI-treated cells[1]. Kazinol B (2-20 μM; 5 days) dose-dependently increases PPARγ and C/EBPα protein and mRNA levels in MDI-treated 3T3-L1 adipocytes. Kazinol B increases the mRNA level of adiponectin in a dose-dependent manner[1]. Kazinol B (2-20 μM; 24 hours) increases the retained 2ʹNBDG-fluorescence in cells in a dose-dependent manner in differentiated 3T3-L1 adipocytes and C2C12 myoblasts. Kazinol B dependently increases the MDI-stimulated GLUT4 mRNA level up to 4.7-fold as compared with MDI-only treated cells[1]. Kazinol B (10-20 μM; pre-treated for 1 h followed by 1 h insulin) dose-dependently increases insulin-dependent Akt phosphorylation. Kazinol B alone strongly induces Akt phosphorylation compared with untreated cells. Kazinol B also increased insulin-stimulated AMPK phosphorylation[1]. Kazinol B (6.25, 12.5, 25, 50 μM; 18 hours) dose-dependently reduces amounts of iNOS protein in macrophages (RAW 264.7 cells) activated by LPS (1 ug/mL)[2]. |
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| References | [1]. Hyejin Lee, et al. Kazinol B from Broussonetia kazinoki improves insulin sensitivity via Akt and AMPK activation in 3T3-L1 adipocytes. Fitoterapia. 2016 Jul;112:90-6. [2]. Jae-Ha Ryu, et al. Fitoterapia. 2003 Jun;74(4):350-4.Inhibition of nitric oxide production on LPS-activated macrophages by kazinol B from Broussonetia kazinoki. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 556.6±50.0 °C at 760 mmHg |
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| Molecular Formula | C25H28O4 |
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| Molecular Weight | 392.487 |
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| Flash Point | 290.4±30.1 °C |
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| Exact Mass | 392.198761 |
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| PSA | 58.92000 |
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| LogP | 6.77 |
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| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
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| Index of Refraction | 1.601 |
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| InChIKey | QSCBHDIGHKHWKC-NRFANRHFSA-N |
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| SMILES | CC(C)=CCc1c(C2CCc3ccc(O)cc3O2)cc2c(c1O)OC(C)(C)C=C2 |
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Safety Information
Synonyms
| (2S)-2',2'-Dimethyl-7'-(3-methyl-2-buten-1-yl)-3,4-dihydro-2H,2'H-2,6'-bichromene-7,8'-diol |
| [2,6'-Bi-2H-1-benzopyran]-7,8'-diol, 3,4-dihydro-2',2'-dimethyl-7'-(3-methyl-2-buten-1-yl)-, (2S)- |
