CAS 73731-87-0|2-[3-(4-Hydroxyphenyl)propyl]-5-methoxyphenol
Introduction：Basic information about CAS 73731-87-0|2-[3-(4-Hydroxyphenyl)propyl]-5-methoxyphenol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 2-[3-(4-Hydroxyphenyl)propyl]-5-methoxyphenol | ||
|---|---|---|---|
| CAS Number | 73731-87-0 | Molecular Weight | 258.312 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 439.5±35.0 °C at 760 mmHg |
| Molecular Formula | C16H18O3 | Melting Point | 101-101.5 °C |
| MSDS | / | Flash Point | 219.6±25.9 °C |
Names
| Name | Broussonin A |
|---|---|
| Synonym | More Synonyms |
BiologicalActivity
| Description | Broussonin A is a potent BChE inhibitor, with an IC50 of 4.16 µM. Broussonin A is a diarylpropane natural product that can be isolated from the bark of Broussonetia papyrifera after solid fermentation[1][2][3]. |
|---|---|
| Related Catalog | Research Areas >>CancerResearch Areas >>Cardiovascular DiseaseSignaling Pathways >>Neuronal Signaling >>AChE |
| Target | BChE:4.16 μM (IC50) |
| In Vitro | Broussonin A（0.1-10 µM，30 分钟）通过调节细胞周期相关蛋白的表达和视网膜母细胞瘤蛋白的磷酸化状态来抑制 VEGF-A 刺激的内皮细胞增殖[1]。 Broussonin A（0-10 µM，30 分钟）消除 VEGF-A 刺激的血管生成反应，包括大鼠主动脉环的内皮细胞迁移、侵袭、管形成和微血管形成[1]。 |
| References | [1]. Kim JH, et al. Broussonin A- and B-mediated inhibition of angiogenesis by blockade of VEGFR-2 signalling pathways and integrin β1 expression. J Cell Mol Med. 2022 Feb;26(4):1194-1205. [2]. Lee JP, et al. Potent inhibition of acetylcholinesterase by sargachromanol I from Sargassum siliquastrum and by selected natural compounds. Bioorg Chem. 2019 Aug;89:103043. [3]. Chang C F, et al. Bioactive compounds from the bark of Broussonetia papyrifera after solid fermentation with a white rot fungus Perenniporia tephropora[J]. Journal of Wood Chemistry and Technology, 2020:1-14. |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 439.5±35.0 °C at 760 mmHg |
| Melting Point | 101-101.5 °C |
| Molecular Formula | C16H18O3 |
| Molecular Weight | 258.312 |
| Flash Point | 219.6±25.9 °C |
| Exact Mass | 258.125580 |
| PSA | 49.69000 |
| LogP | 3.65 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.600 |
| InChIKey | MSNVBURPCQDLEP-UHFFFAOYSA-N |
| SMILES | COc1ccc(CCCc2ccc(O)cc2)c(O)c1 |
Synonyms
| 2-[3-(4-Hydroxyphenyl)propyl]-5-methoxyphenol |
| Phenol, 2-[3-(4-hydroxyphenyl)propyl]-5-methoxy- |
