Introduction：Basic information about CAS 675126-26-8|Gefitinib impurity 1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Gefitinib impurity 1 |
|---|
| CAS Number | 675126-26-8 | Molecular Weight | 321.328 |
|---|
| Density | 1.3±0.1 g/cm3 | Boiling Point | 522.3±50.0 °C at 760 mmHg |
|---|
| Molecular Formula | C15H19N3O5 | Melting Point | / |
|---|
| MSDS | / | Flash Point | 269.7±30.1 °C |
|---|
Names
| Name | 4-methoxy-5-(3-morpholin-4-ylpropoxy)-2-nitrobenzonitrile |
|---|
| Synonym | More Synonyms |
|---|
Gefitinib impurity 1 BiologicalActivity
| Description | Gefitinib impurity 1 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2]. |
|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
|---|
| References | [1]. Wakeling AE, et al. ZD1839: an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy. Cancer Res. 2002 Oct 15;62(20):5749-54. |
|---|
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|
| Boiling Point | 522.3±50.0 °C at 760 mmHg |
|---|
| Molecular Formula | C15H19N3O5 |
|---|
| Molecular Weight | 321.328 |
|---|
| Flash Point | 269.7±30.1 °C |
|---|
| Exact Mass | 321.132477 |
|---|
| PSA | 100.54000 |
|---|
| LogP | 1.50 |
|---|
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
|---|
| Index of Refraction | 1.570 |
|---|
| InChIKey | FYCDMKYKGPHRFW-UHFFFAOYSA-N |
|---|
| SMILES | COc1cc([N+](=O)[O-])c(C#N)cc1OCCCN1CCOCC1 |
|---|
Safety Information
Synonyms
| Benzonitrile, 4-methoxy-5-[3-(4-morpholinyl)propoxy]-2-nitro- |
| y6567 |
| 4-Methoxy-5-[3-(4-morpholinyl)propoxy]-2-nitrobenzonitrile |
| 4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile |
| 2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile |
| Benzonitrile,4-methoxy-5-[3-(4-morpholinyl)propoxy]-2-nitro- |
