Introduction：Basic information about CAS 1259305-29-7|Aripiprazole lauroxil, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Aripiprazole lauroxil |
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| CAS Number | 1259305-29-7 | Molecular Weight | 660.71400 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C36H51Cl2N3O4 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | [7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-2-oxo-3,4-dihydroquinolin-1-yl]methyl dodecanoate |
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| Synonym | More Synonyms |
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Aripiprazole lauroxil BiologicalActivity
| Description | Aripiprazole lauroxil, an N-acyloxymethyl prodrug of aripiprazole, is a Long-acting injectable (LAI) typical antipsychotic for schizophrenia. Aripiprazole lauroxil is cleaved by body’s enzyme esterase to N-hydroxymethyl aripiprazole (plus lauric acid) and then to aripiprazole (plus formaldehyde), no toxicity[1]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
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| In Vivo | Aripiprazole lauroxil (intravenous administration; 1.87 mg/ml) bioconversion in vivo involves the formation of an intermediate, N-hydroxymethyl aripiprazole, the in vitro data indicates a high bioconversion of aripiprazole lauroxil, thus, the concentration of N-hydroxymethyl aripiprazole observed in the animals dosed with aripiprazole lauroxil is surprisingly high[1]. Animal Model: Female Sprague Dawley rats[1] Dosage: 1.87 mg/ml Administration: Blood samples is taken at 5, 15, 30 min and 1, 2, 4, 6, 8 and 24 h after administration Result: Exhibits an clearance: 0.32 ± 0.11 L/h/kg. |
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| References | [1]. Jann MW, et al. Long-Acting Injectable Second-Generation Antipsychotics: An Update and Comparison Between Agents.CNS Drugs. 2018 Mar;32(3):241-257. [2]. Rohde M, et al. Biological conversion of aripiprazole lauroxil - An N-acyloxymethyl aripiprazole prodrug.Results Pharma Sci. 2014 May 2;4:19-25. |
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Chemical & Physical Properties
| Molecular Formula | C36H51Cl2N3O4 |
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| Molecular Weight | 660.71400 |
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| Exact Mass | 659.32600 |
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| PSA | 62.32000 |
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| LogP | 8.74330 |
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| InChIKey | DDINXHAORAAYAD-UHFFFAOYSA-N |
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| SMILES | CCCCCCCCCCCC(=O)OCN1C(=O)CCc2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc21 |
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| Storage condition | 2~8°C |
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Safety Information
Synonyms
| Aripiprazole lauroxil (USAN) |
| Aripiprazole lauroxil |
| UNII-B786J7A343 |
| (7-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)-2-oxo-3,4-dihydroquinolin-1(2H)-yl)methyl dodecanoate |
| RDC-3317 |
