CAS 112732-17-9|Enrofloxacin hydrochloride

Introduction：Basic information about CAS 112732-17-9|Enrofloxacin hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Enrofloxacin hydrochloride BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Enrofloxacin hydrochloride
CAS Number	112732-17-9	Molecular Weight	395.856
Density	1.385g/cm3	Boiling Point	560.5ºC at 760mmHg
Molecular Formula	C₁₉H₂₂FN₃O_3.xHCl	Melting Point	/
MSDS	/	Flash Point	292.8ºC

Names

Name	Enrofloxacin hydrochloride
Synonym	More Synonyms

Enrofloxacin hydrochloride BiologicalActivity

Description	Enrofloxacin hydrochloride is an effective antibiotic with an MIC90 of 0.312 μg/mL for Mycoplasma bovis.
Related Catalog	Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Infection
Target	MIC90: 0.312 μg/mL ( Mycoplasma bovis)[1]
In Vitro	Mycoplasma bovis is a worldwide pathogen, causative agent of pneumonia, mastitis, arthritis, and a variety of other symptoms in cattle. The antibiotic susceptibility profiles of the Hungarian strains are consistent within the tested group of fluoroquinolones. Three isolates (MYC44, MYC45 and MYC46) have high MIC values (≥10 μg/mL) to Enrofloxacin, while the rest of the strains are inhibited by Enrofloxacin with MICs ≤0.312 or 0.625 μg/mL[1].
In Vivo	Mice (n=80) undergo transient middle cerebral artery occlusion (MCAo) with reperfusion after 60 minutes. After MCAo, animals are randomly assigned to receive either a daily preventive medication (n=26, Enrofloxacin) starting at the day of MCAo or a therapeutic medication (n=25; Enrofloxacin) after diagnosis of lung infection. Standard treatment started immediately after the appearance of clinical signs (general health score>6) usually between day 4 and 6 after stroke. Both, preventive and standard antibiotic treatment using Enrofloxacin improve survival in a similar way compared with placebo treatment[2].
Animal Admin	Mice[2] 11- to 14-week-old C57Bl6/J male mice are used. Enrofloxacin (2.5% oral solution) is dispensed in saline (2 mg/mL), antibiotic-treated animals receive a daily orally dispensed dose of 10 mg/kg body weight via feeding needle every 12 hours over a period of 7 days, while placebo animals receive the same amount of saline via feeding needle. Animals of preventive antibiotic group obtained Enrofloxacin after waking from reperfusion anesthesia (ca. 1 hour after operation). Therapeutic antibiotic treatment is given immediately after appearance of clinical signs (general health score>5) and confirmation of lung infection by MRI (signal rate≥5%). The group allocation is randomized[2].
References	[1]. Sulyok KM, et al.Antibiotic susceptibility profiles of Mycoplasma bovis strains isolated from cattle in Hungary, Central Europe. BMC Vet Res. 2014 Oct 25;10:256. [2]. Hetze S, et al. Superiority of preventive antibiotic treatment compared with standard treatment of poststroke pneumonia in experimental stroke: a bed to bench approach. J Cereb Blood Flow Metab. 2013 Jun;33(6):846-54.

Chemical & Physical Properties

Density	1.385g/cm3
Boiling Point	560.5ºC at 760mmHg
Molecular Formula	C₁₉H₂₂FN₃O_3.xHCl
Molecular Weight	395.856
Flash Point	292.8ºC
Exact Mass	395.141205
PSA	65.78000
LogP	3.12050
Vapour Pressure	2.57E-14mmHg at 25°C
InChIKey	PZJWYUDBXNNVLZ-UHFFFAOYSA-N
SMILES	CCN1CCN(c2cc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)CC1.Cl
Storage condition	0-6°C

Safety Information

WGK Germany	3
RTECS	VB1993650

Synonyms

Enrofloxacin hydrochloride salt

1-Cyclopropyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride (1:1)

Enorfloxacin HCL

EenrofloxacinHydrochloride

Enrofloxacin Hydrochloide

BAYTRIL

3-Quinolinecarboxylic acid, 1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-, hydrochloride (1:1)

MFCD00792463

1-Cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid hydrochloride (1:1)

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