Introduction：Basic information about CAS 26046-85-5|D-Phenothrin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | D-Phenothrin |
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| CAS Number | 26046-85-5 | Molecular Weight | 350.45100 |
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| Density | 1.12 g/cm3 | Boiling Point | 437ºC at 760 mmHg |
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| Molecular Formula | C23H26O3 | Melting Point | / |
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| MSDS | / | Flash Point | 186.6ºC |
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Names
| Name | (3-phenoxyphenyl)methyl (1R,3R)-2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropane-1-carboxylate |
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| Synonym | More Synonyms |
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D-Phenothrin BiologicalActivity
| Description | D-Phenothrin ((-)-trans-Phenothrin), an orally active Type II synthetic pyrethroid, is widely used to kill insects, mosquitoes, and human lice. D-Phenothrin is also used in veterinary medicine to control insect pests on animals and protect agricultural crops[1]. |
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| Related Catalog | Research Areas >>Infection |
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| In Vivo | D-Phenothrin ((-)-trans-Phenothrin; 25-200 mg/kg; IP; 14 consecutive days) significantly, dose-dependently increases oxidative DNA damage in both organs of animals[1]. D-Phenothrin (100, 300 or 1000 mg/kg/day; p.o.; 3 days) exhibits no potential to cause adverse estrogenic or (anti-)androgenic effects[2]. Animal Model: Male Wistar albino rats (6-week-old, 150-200 g) Dosage: 25, 50, 100, 200 mg/kg Administration: IP; 14 consecutive days Result: Had a statistically significant, dose-dependent increase in oxidative DNA damage in both organs of animals. |
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| References | [1]. Atmaca E, et al. d-Phenothrin-induced oxidative DNA damage in rat liver and kidney determined by HPLC-ECD/DAD. Environ Toxicol. 2015 May;30(5):607-13. [2]. Yamada T, et al. Lack of estrogenic or (anti-)androgenic effects of d-phenothrin in the uterotrophic and Hershberger assays. Toxicology. 2003 Apr 22;186(3):227-39. |
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Chemical & Physical Properties
| Density | 1.12 g/cm3 |
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| Boiling Point | 437ºC at 760 mmHg |
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| Molecular Formula | C23H26O3 |
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| Molecular Weight | 350.45100 |
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| Flash Point | 186.6ºC |
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| Exact Mass | 350.18800 |
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| PSA | 35.53000 |
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| LogP | 5.76050 |
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| Vapour Pressure | 0mmHg at 25°C |
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| Index of Refraction | 1.588 |
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| InChIKey | SBNFWQZLDJGRLK-RTWAWAEBSA-N |
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| SMILES | CC(C)=CC1C(C(=O)OCc2cccc(Oc3ccccc3)c2)C1(C)C |
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| Storage condition | 0-6°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- GZ2002530
- CHEMICAL NAME :
- Cyclopropanecarboxylic acid, 2,2-dimethyl-3-(2-methyl-1-propenyl)-, (3-phenoxyphenyl) methyl ester, (1R-trans)-
- CAS REGISTRY NUMBER :
- 26046-85-5
- LAST UPDATED :
- 199112
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C23-H26-O3
- MOLECULAR WEIGHT :
- 350.49
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (37),30,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Amphibian - frog
- DOSE/DURATION :
- >20 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971- Volume(issue)/page/year: 20,217,1983
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Safety Information
| Hazard Codes | Xi |
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| Risk Phrases | R36/37/38:Irritating to eyes, respiratory system and skin . |
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| Safety Phrases | S24/25-S37/39-S26 |
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Synonyms
| biophenothrin |
| trans-4-Hydroxy-1-hydroxymethyl-cyclohexan |
| EINECS 247-431-2 |
| 1-Chlor-trans,trans-dimethylcyclopropan |
| 1r-Chlor-2t,3t-dimethyl-cyclopropan |
| 1-Chlor-2,3-cis-dimethylcyclopropan |
| trans-4-Hydroxycyclohexylcarbinol |
| trans-4-Hydroxymethyl-cyclohexanol |
| 1R-trans-Phenothrin |
| MFCD01735786 |
| 1r-chloro-2t,3t-dimethyl-cyclopropane |
| D-Phenothrin |
