Introduction：Basic information about CAS 1161-13-3|N-Cbz-L-Phenylalanine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Research Areas >>OthersSignaling Pathways >>Others >>Others
In Vitro
Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].
References
[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-883.
Chemical & Physical Properties
Density
1.2±0.1 g/cm3
Boiling Point
511.5±50.0 °C at 760 mmHg
Melting Point
85-87 °C(lit.)
Molecular Formula
C17H17NO4
Molecular Weight
299.321
Flash Point
263.1±30.1 °C
Exact Mass
299.115753
PSA
75.63000
LogP
3.58
Vapour Pressure
0.0±1.4 mmHg at 25°C
Index of Refraction
1.591
InChIKey
RRONHWAVOYADJL-HNNXBMFYSA-N
SMILES
O=C(NC(Cc1ccccc1)C(=O)O)OCc1ccccc1
Toxicological Information
CHEMICAL IDENTIFICATION
RTECS NUMBER :
AY4343000
CHEMICAL NAME :
Alanine, N-carboxy-3-phenyl-, N-benzyl ester, L-
CAS REGISTRY NUMBER :
1161-13-3
LAST UPDATED :
199206
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C17-H17-N-O4
MOLECULAR WEIGHT :
299.35
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
251 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 67,1726,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravaginal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 68,696,1979 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
280 mg/kg
SEX/DURATION :
female 28 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 68,696,1979
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravaginal
DOSE :
280 mg/kg
SEX/DURATION :
female 28 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 68,696,1979
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
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