Introduction：Basic information about CAS 1138-80-3|Z-Gly-OH, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Research Areas >>OthersSignaling Pathways >>Others >>Others
In Vitro
Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].
References
[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.
Chemical & Physical Properties
Density
1.3±0.1 g/cm3
Boiling Point
424.0±38.0 °C at 760 mmHg
Melting Point
118-122 °C(lit.)
Molecular Formula
C10H11NO4
Molecular Weight
209.199
Flash Point
210.2±26.8 °C
Exact Mass
209.068802
PSA
75.63000
LogP
1.37
Vapour Pressure
0.0±1.1 mmHg at 25°C
Index of Refraction
1.554
InChIKey
CJUMAFVKTCBCJK-UHFFFAOYSA-N
SMILES
O=C(O)CNC(=O)OCc1ccccc1
Water Solubility
methanol: 0.1 g/mL, clear
Toxicological Information
CHEMICAL IDENTIFICATION
RTECS NUMBER :
MB9129000
CHEMICAL NAME :
Glycine, N-carboxy-, N-benzyl ester
CAS REGISTRY NUMBER :
1138-80-3
BEILSTEIN REFERENCE NO. :
0526877
LAST UPDATED :
199701
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C10-H11-N-O4
MOLECULAR WEIGHT :
209.22
WISWESSER LINE NOTATION :
QVN1R&1VQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravaginal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
380 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 68,696,1979 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
280 mg/kg
SEX/DURATION :
female 28 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 70,60,1981
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravaginal
DOSE :
280 mg/kg
SEX/DURATION :
female 28 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 70,60,1981
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Articles4
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J. Pharm. Pharmacol. 51 , 549-553, (1999)
Glycine, which has weak anticonvulsant properties, has been shown to potentiate the activity of several antiepileptic drugs but not phenytoin. Recently, studies have shown that N-(benzyloxycarbonyl)gl...
