CAS 1404-04-2|Neomycin
Introduction：Basic information about CAS 1404-04-2|Neomycin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Neomycin | ||
|---|---|---|---|
| CAS Number | 1404-04-2 | Molecular Weight | 614.644 |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 927.1±65.0 °C at 760 mmHg |
| Molecular Formula | C23H52N6O25S3 | Melting Point | / |
| MSDS | Chinese | Flash Point | 514.5±34.3 °C |
Names
| Name | neomycin sulfate |
|---|---|
| Synonym | More Synonyms |
Neomycin BiologicalActivity
| Description | Neomycin is an aminoglycoside antibiotic. Neomycin can be used for the research of external or internal bacterial infections, is primarily administered in veterinary medicine as a sulfate salt[1]. |
|---|---|
| Related Catalog | Research Areas >>Infection |
| References | [1]. Liu Y, et al. Pharmacokinetics of neomycin sulfate after intravenous and oral administrations in swine. J Vet Pharmacol Ther. 2021 Sep;44(5):850-853. |
Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 927.1±65.0 °C at 760 mmHg |
| Molecular Formula | C23H52N6O25S3 |
| Molecular Weight | 614.644 |
| Flash Point | 514.5±34.3 °C |
| Exact Mass | 614.312256 |
| PSA | 602.05000 |
| LogP | -3.65 |
| Appearance of Characters | powder |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.675 |
| InChIKey | PGBHMTALBVVCIT-UHFFFAOYSA-N |
| SMILES | NCC1OC(OC2C(CO)OC(OC3C(O)C(N)CC(N)C3OC3OC(CN)C(O)C(O)C3N)C2O)C(N)C(O)C1O |
| Storage condition | 2-8°C |
| Water Solubility | H2O: 50 mg/mL As a stock solution. Stock solutions should be filter sterilized and stored at 2-8°C. Stable at 37°C for 5 days. |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 220 mg/kg/2D
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Ear) - change in acuity Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - urine volume decreased
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 57 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Ear) - changes in cochlear structure or function Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2750 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 633 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2880 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 116 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 275 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 27600 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 mg/kg/5D-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
MUTATION DATA - TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 50 mg/kg
- REFERENCE :
- CHRTBC Chromosomes Today. (George Allen & Unwin Ltd., 40 Museum St., London WC1A 1LU, UK) V.1- 1966- Volume(issue)/page/year: 4,277,1973 *** REVIEWS *** TOXICOLOGY REVIEW CPJOAC Canadian Pharmaceutical Journal. (Canadian Pharmaceutical Assoc., 101-1815 Alta Vista Dr., Ottawa, Ont., Canada) V.1- 1868- Volume(issue)/page/year: 108(3),88,1975 TOXICOLOGY REVIEW CLANA4 Clinical Anesthesia. (Philadelphia, PA 19103) V.1-11, 1963-76. Volume(issue)/page/year: 10(Pt 1),283,1973 TOXICOLOGY REVIEW MMWOAU Muenchener Medicinische Wochenschrift. (Munich, Fed. Rep. Ger.) V.33-115, 1886-1973. Volume(issue)/page/year: 115,1661,1973 TOXICOLOGY REVIEW AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 38,409,1965 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3705 No. of Facilities: 567 (estimated) No. of Industries: 2 No. of Occupations: 11 No. of Employees: 19997 (estimated) No. of Female Employees: 16532 (estimated)
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 50 mg/kg
- REFERENCE :
- CHRTBC Chromosomes Today. (George Allen & Unwin Ltd., 40 Museum St., London WC1A 1LU, UK) V.1- 1966- Volume(issue)/page/year: 4,277,1973 *** REVIEWS *** TOXICOLOGY REVIEW CPJOAC Canadian Pharmaceutical Journal. (Canadian Pharmaceutical Assoc., 101-1815 Alta Vista Dr., Ottawa, Ont., Canada) V.1- 1868- Volume(issue)/page/year: 108(3),88,1975 TOXICOLOGY REVIEW CLANA4 Clinical Anesthesia. (Philadelphia, PA 19103) V.1-11, 1963-76. Volume(issue)/page/year: 10(Pt 1),283,1973 TOXICOLOGY REVIEW MMWOAU Muenchener Medicinische Wochenschrift. (Munich, Fed. Rep. Ger.) V.33-115, 1886-1973. Volume(issue)/page/year: 115,1661,1973 TOXICOLOGY REVIEW AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 38,409,1965 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3705 No. of Facilities: 567 (estimated) No. of Industries: 2 No. of Occupations: 11 No. of Employees: 19997 (estimated) No. of Female Employees: 16532 (estimated)
Safety Information
| Hazard Codes | Xn: Harmful; |
|---|---|
| Risk Phrases | R42/43 |
| Safety Phrases | S22;S45;S36/S37 |
| WGK Germany | 3 |
| RTECS | QP4375000 |
Synonyms
| Actilin |
| neomin |
| Neosulf |
| neomcin |
| nivemycin |
| Myacine |
| EINECS 215-773-1 |
| NEOMIX |
| Endomixin |
| Bykomycin |
| Neobiosamine B |
| Framygen |
| Jernadex |
| Antibiotique EF 185 |
| (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-b-L-idopyranosyl)-b-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-a-D-glucopyranoside |
| myacyne |
| Enterfram |
| α-D-Glucopyranoside, (1R,2R,3S,4R,6S)-4,6-diamino-2-[[3-O-(2,6-diamino-2,6-dideoxy-β-L-idopyranosyl)-β-D-ribofuranosyl]oxy]-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy- |
| Bycomycin |
| neolate |
| Neomyacin |
| Neobrettin |
| Framycetin |
| Biosol |
| Tuttomycin |
| a-D-glucopyranoside, (1R,2R,3S,4R,6S)-4,6-diamino-2-[[3-O-(2,6-diamino-2,6-dideoxy-b-L-idopyranosyl)-b-D-ribofuranosyl]oxy]-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy- |
| Fraquinol |
| Neomycin |
| (1R,2R,3S,4R,6S)-4,6-Diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-β-L-idopyranosyl)-β-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-α-D-glucopyranoside |
| neomas |
