CAS 426-13-1|fluoromethalone

Introduction：Basic information about CAS 426-13-1|fluoromethalone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. fluoromethalone BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles45
8. Synonyms

Common Name	fluoromethalone
CAS Number	426-13-1	Molecular Weight	376.462
Density	1.3±0.1 g/cm3	Boiling Point	527.1±50.0 °C at 760 mmHg
Molecular Formula	C₂₂H₂₉FO₄	Melting Point	292 - 303ºC
MSDS	ChineseUSA	Flash Point	272.6±30.1 °C
Symbol	GHS07	Signal Word	Warning

Names

Name	fluorometholone
Synonym	More Synonyms

fluoromethalone BiologicalActivity

Description	Fluorometholone, a synthetic glucocorticoid, is a glucocorticoid receptor agonist with anti-inflammatory and anti-allergic properties. Fluorometholone can be used in the management of dry eye[1].
Related Catalog	Research Areas >>Inflammation/ImmunologySignaling Pathways >>GPCR/G Protein >>Glucocorticoid Receptor
Target	glucocorticoid receptor[1]
In Vitro	Fluorometholone (25-100 nM; 12 hours, 24 hours) increases the gene expression of MUC1, MUC4, MUC16 and MUC19 in the conjunctival and corneal epithelial cells through activation of glucocorticoid receptors[1].
References	[1]. Jonathan Taniguchi, et al. Fluorometholone Modulates Gene Expression of Ocular Surface Mucins. Acta Ophthalmol. 2019 Dec;97(8):e1082-e1088.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	527.1±50.0 °C at 760 mmHg
Melting Point	292 - 303ºC
Molecular Formula	C₂₂H₂₉FO₄
Molecular Weight	376.462
Flash Point	272.6±30.1 °C
Exact Mass	376.204987
PSA	74.60000
LogP	2.02
Vapour Pressure	0.0±3.1 mmHg at 25°C
Index of Refraction	1.574
InChIKey	FAOZLTXFLGPHNG-KNAQIMQKSA-N
SMILES	CC(=O)C1(O)CCC2C3CC(C)C4=CC(=O)C=CC4(C)C3(F)C(O)CC21C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU3834100

CHEMICAL NAME :: Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-6-methyl-, (6-alpha,11-beta)-

CAS REGISTRY NUMBER :: 426-13-1

LAST UPDATED :: 199710

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C22-H29-F-O4

MOLECULAR WEIGHT :: 376.51

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 8,2349,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 443 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,981,1990

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 8,2349,1974 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2800 ug/kg/28D-I

TOXIC EFFECTS :: Endocrine - changes in thymus weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Metabolism (Intermediary) - lipids including transport

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 8,2349,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3684 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 82 (estimated) No. of Female Employees: 14 (estimated)

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H312-H332
Precautionary Statements	P280
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R20/21/22
Safety Phrases	S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	TU3834100
HS Code	2937229000

Customs

HS Code	2937229000

Articles45

Peripheral deep anterior lamellar keratoplasty using a cryopreserved donor cornea for Terrien's marginal degeneration.

J. Zhejiang Univ. Sci. B 15(12) , 1055-63, (2014)

To evaluate the clinical efficacy of peripheral deep anterior lamellar keratoplasty (DALK) using a cryopreserved donor cornea for Terrien's marginal degeneration (TMD).Thirty-one eyes of 27 patients w...

Comparison of Corneal Biomechanical Characteristics After Surface Ablation Refractive Surgery and Novel Lamellar Refractive Surgery.

Cornea 34 , 1441-6, (2015)

To investigate and compare corneal biomechanical changes in the form of corneal hysteresis (CH) and corneal resistance factor (CRF) after small-incision lenticule extraction (SMILE) and laser-assisted...

Big bubble deep anterior lamellar keratoplasty for management of deep fungal keratitis.

J. Ophthalmol. 2014 , 209759, (2014)

Objective. To evaluate the therapeutic effect of big bubble deep anterior lamellar keratoplasty (DALK) in patients with deep fungal keratitis. Methods.Consecutive patients who had DALK for deep fungal...

Synonyms

(6S,8S,9R,10S,11S,13S,14S,17R)-17-acétyl-9-fluoro-11,17-dihydroxy-6,10,13-triméthyl-6,7,8,9,10,11,12,13,14,15,16,17-dodécahydro-3H-cyclopenta[a]phénanthrén-3-one

EINECS 207-041-5

Fluoromethalone

21-Desoxy-6a-methyl-9a-fluoroprednisolone

(6α,11β)-9-Fluoro-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione

Fluormetholon

fluorometholone

FLAREX

Efflumidex

9-Fluoro-11,17-Dihydroxy-6-Methylpregna-1,4-Diene-3,20-Dione

21-Desoxy-9a-fluoro-6a-methylprednisolone

Loticort

Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17-dihydroxy-6α-methyl-

MFCD00056461

(6a,11b)-9-Fluoro-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione

(6S,8S,9R,10S,11S,13S,14S,17R)-17-Acetyl-9-fluor-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-on

(6S,8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one

Fluaton

Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-6-methyl-, (6α,11β)-

Ursnon

Fluoro methalone

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